Abstract
The interaction ofd-amphetamine with several brain tissue components has been investigated. A brain lipid extract and a number of individual phospholipids were found to bindd-amphetamine when measured by means of a hexane-buffer partition coefficient technique. Phosphatidylserine showed the greatest binding and phosphatidylethanolamine and dipalmitoyllecithin were also effective. Phospholipid binding ofd-amphetamine was shown to be related to fatty acid composition. Cholesterol and ganglioside did not bind. It is suggested that phospholipid binding ofd-amphetamine may play a role in the pharmacological action of this drug.
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Goldberg, M.A., Todoroff, T. d-amphetamine binding to brain lipid. Neurochem Res 3, 763–773 (1978). https://doi.org/10.1007/BF00965999
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DOI: https://doi.org/10.1007/BF00965999