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Increase of ornithine decarboxylase activity elicited by reserpine in the peripheral and central monoaminergic systems of the rat

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Abstract

Ornithine decarboxylase activity was increased about tenfold in adrenal glands and in brain regions preponderantly containing aminergic neurons, by a single dose of 16 μmol/kg of reserpine. Maximal enzyme activity in the adrenal glands was observed at about 8 hr after reserpine administration. The ornithine decarboxylase activity-time curves in the brain regions showed a concomitant polyphasic course, with the highest maximum at 12 hr postinjection. Ornithine decarboxylase induction is discussed as an early event in the cascade of molecular events preceding the induction of cell typic enzymes.

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Author notes

  1. Klaus Deckardt

    Present address: Badische Anilin und Sodafabrik, 67, Ludwigshafen (Rhein)

  2. Nikolaus Seiler

    Present address: Centre de Recherche Merrell International, 16, rue d'Ankara, 67000, Strasbourg, France

Authors and Affiliations

  1. Max-Planck Institut für Hirnforschung, 6000, Frankfurt a.M.-Niederrad, G.F.R.

    Klaus Deckardt & Nikolaus Seiler

  2. Laboratoire de Médecine Expérimentale, 8, avenue Rockefeller 69373, Lyon Cedex 2, France

    Jean-François Pujol, Marie-Françoise Belin & Michel Jouvet

Authors
  1. Klaus Deckardt
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  2. Jean-François Pujol
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  3. Marie-Françoise Belin
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  4. Nikolaus Seiler
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  5. Michel Jouvet
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Deckardt, K., Pujol, JF., Belin, MF. et al. Increase of ornithine decarboxylase activity elicited by reserpine in the peripheral and central monoaminergic systems of the rat. Neurochem Res 3, 745–753 (1978). https://doi.org/10.1007/BF00965997

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  • DOI: https://doi.org/10.1007/BF00965997

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