Neurochemical Research

, Volume 3, Issue 6, pp 725–731 | Cite as

A possible mechanism for cholesteryl ester formation during demyelination

Lecithin: Cholesterol acyltransferase (LCAT) activity in rat brain
  • L. Amaducci
  • P. Antuono
  • L. Bartolini
  • G. E. De Medio
  • D. Inzitari
  • G. Porcellati
Original Articles


Lecithin: cholesterol acyltransferase (LCAT) activity has been examined in the rat by using a brain homogenate preparation as the phospholipid substrate and blood plasma as the enzyme source. LCAT activity was detected on using 60 μl of serum onwards. Successive experiments have also shown that LCAT activity is present in the edematous rat brain tissue homogenate when incubated with inactivated rat plasma as substrate. The results are discussed in relation to cholesteryl ester accumulation in brain during demyelinating diseases.


Lecithin Cholesteryl Ester Brain Homogenate Demyelinating Disease Ester Formation 
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • L. Amaducci
    • 1
  • P. Antuono
    • 1
  • L. Bartolini
    • 1
  • G. E. De Medio
    • 2
  • D. Inzitari
    • 1
  • G. Porcellati
    • 2
  1. 1.Neurological ClinicUniversity of FlorenceFlorenceItaly
  2. 2.Department of Biochemistry, The Medical SchoolUniversity of PerugiaPerugiaItaly

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