Rat brain monoamine and serotonin S2 receptor changes during pregnancy
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The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decrease in striatal and frontal cortex 5-hydroxyindole-3-acetic acid (5-HIAA) concentration was observed in 15 day pregnant rats. Significant increases in hypothalamic and hippocampal NA levels were observed at 4 days post-partum. Frontal cortex serotonin S2 receptorKd was reduced in 4 day post-partum rats. There was no significant change in S2 receptorBmax during pregnancy. Levels of progesterone were negatively correlated with striatal DA, homovanillic acid (HVA), 5-HT, and 5-HIAA levels, hypothalamic DA, hippocampal 5-HT, and frontal cortex 5-HIAA values as well as striatal HVA to DA, and HVA to 3,4-dihydroxyphenylacetic acid (DOPAC) ratios and amygdaloid HVA to DOPAC ratios. The limbic neurotransmitter changes might possibly contribute to mood changes which occur during pregnancy and post-partum.
Key WordsDopamine noradrenaline serotonin S2 receptors progesterone estradiol-17β corticosterone limbic system pregnancy
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- 10.Findder, J. M., and Tonge, S. R. 1975. Variations in the concentrations of monoamines and their metabolites in eight regions of rat brain during the estrous cycle: a basis for interactions between hormones and psychotrophic drugs. J. Pharm. Pharmacol. 27:39P.Google Scholar
- 19.Miller, G. L. 1959. Protein determination for large numbers of samples. Anal. Chem. 31:964.Google Scholar
- 20.Scatchard, G. 1949. The attractions of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. 51:660–672.Google Scholar
- 29.Zuspan, F. P., Nelson, G. H., Ahlquist, R. P., and Williams, S. 1967. Alterations of urinary epinephrine and norepinephrine. The antepartum, intrapartum, and postpartum periods. Am. J. Obs. Gyne. 99:709–721.Google Scholar
- 30.Van Praag, H. M. 1982. Neurotransmitters and CNS disease. Depression. Lancet II (8310):1259–1264.Google Scholar
- 31.Peabody, C. A., Faull, K. F., King, R. J., Whiteford, H. A., Barchas, J. D., and Berger, P. A. 1986. CSF amine metabolites and depression. Psychiat. Res. 21:1–7.Google Scholar
- 33.Ramirez, O. A., and Carrer, H. F. 1982. Effects of estrogen and progesterone priming on the uptake and release of serotonin and noradrenaline from the ventromedial hypothalamus. Acta physiol. latinoam. 32:313–319.Google Scholar
- 34.Breuer, H., and Köster, G. 1974. Interaction between oestrogens and neurotransmitters at the hypophysial-hypothalamic level. J. Steroid Biochem. 5:961–967.Google Scholar