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Effects of injection of 3-acetylpyridine on the levels of taurine in the cerebellum and medulla of the rat: A reappraisal

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Abstract

Values for taurine in a 5% TCA extract of whole rat medulla were decreased by 19% after acid hydrolysis of samples. Values for taurine in a similar extract of rat cerebellum were unaffected by hydrolysis. The values for taurine were lower in the medulla and cerebellum of 3-acetylpyridine treated rat (65 mg/kg i.p.) when the unhydrolyzed TCA extract was assayed. However, when the hydrolyzed TCA extract was assayed, the level of taurine in the medulla was not lower in the 3-AP treatment rat but it was reduced in the cerebella of the drug-treated group. 3-Acetylpyridine appeared to reduce the levels in the medulla of acid-labile compounds which can interfere with the estimation of taurine.

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Author notes

  1. B. H. Rohde

    Present address: Department of Pharmacology, University of Missouri Health Sciences Center, 65212, Columbia, Missouri, USA

Authors and Affiliations

  1. Departments of Psychiatry and Biochemistry The Institute of Psychiatric Research, Indiana University School of Medicine, 46223, Indianapolis, Indiana

    B. H. Rohde & W. J. McBride (Recipient of Research Scientist Developmental Award MH00203)

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  1. B. H. Rohde
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  2. W. J. McBride
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Rohde, B.H., McBride, W.J. Effects of injection of 3-acetylpyridine on the levels of taurine in the cerebellum and medulla of the rat: A reappraisal. Neurochem Res 7, 845–848 (1982). https://doi.org/10.1007/BF00965678

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  • DOI: https://doi.org/10.1007/BF00965678

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