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Arachidonic acid and arachidonoyldiglycerols increase in rat cerebrum during bicuculline-induced status epilepticus

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Abstract

Bicuculline-induced status epilepticus was found to be associated with increased amounts offree fatty acids and diacylglycerols in the rat cerebrum. The predominant fatty acid in both lipid pools was arachidonic acid. The accumulation of arachidonoyl-diglycerols decreased at the time of and during behavioral seizures induced by bicuculline, while the amount of free arachidonic acid appeared to increase. We propose a metabolic relationship between these lipids to explain the described changes. The similarities between the composition of the lipid pools and the fatty acid composition of phosphatidylinositol support the hypothesis that these changes may be a result of a convulsion-activated degradation of this phospholipid from excitable membranes.

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Author notes

  1. Nicolas G. Bazan

    Present address: LSU Medical Center School of Medicine, LSU Eye Center, 136 S. Roman Street, 70112, New Orleans, LA

Authors and Affiliations

  1. Instituto de Investigaciones Bioquimicas, Universidad Nacional del Sur-Consejo Nacional de Investigaciones Cientificas y Tecnicas, Gorriti 43, Bahia Blanca, Argentina

    Nicolas G. Bazan, Susana A. Morelli de Liberti & Elena B. Rodriguez de Turco

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  1. Nicolas G. Bazan
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  2. Susana A. Morelli de Liberti
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  3. Elena B. Rodriguez de Turco
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Bazan, N.G., Morelli de Liberti, S.A. & Rodriguez de Turco, E.B. Arachidonic acid and arachidonoyldiglycerols increase in rat cerebrum during bicuculline-induced status epilepticus. Neurochem Res 7, 839–843 (1982). https://doi.org/10.1007/BF00965677

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  • DOI: https://doi.org/10.1007/BF00965677

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