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The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat

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Abstract

The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine (MSO) in 7 rat brain regions, the spinal cord, the liver, and the kidney was investigated. The administration of methionine decreased the uptake of MSO in all brain regions. The uptake of MSO by and its distribution in the nervous tissue was uniform and failed to result in any preferential accumulation of the drug. Methionine decreased the amount of MSO bound to cerebral structures and to the spinal cord. MSO bound to the spinal cord was less susceptible to release by Triton X-100 than was brain-bound MSO.

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Authors and Affiliations

  1. Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48014, Ann Arbor, Michigan

    Robert A. Schatz, Ronald Harris & Otto Z. Sellinger

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  1. Robert A. Schatz
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  2. Ronald Harris
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  3. Otto Z. Sellinger
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Schatz, R.A., Harris, R. & Sellinger, O.Z. The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat. Neurochem Res 1, 53–63 (1976). https://doi.org/10.1007/BF00965631

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  • DOI: https://doi.org/10.1007/BF00965631

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