Neurochemical Research

, Volume 11, Issue 7, pp 949–957 | Cite as

Modulation of the serotonin S2-receptor in brain after chronic lithium

  • Isabel J. Wajda
  • Miriam Banay-Schwartz
  • Isaac Manigault
  • Abel Lajtha
Original Articles

Abstract

In vivo effects of chronic lithium administration on dopaminergic and serotonergic receptor binding were studied in the striatum and cerebral cortex of the rat. [3H]Domperidone was used as the ligand for the dopaminergic receptor, and [3H]ketanserin for the serotonergic system. Long-term ingestion of lithium (2–3 months) resulted in high levels of lithium in the cerebral cortex and significantly higher potassium levels; the sodium content remained at normal levels. The kinetic constants (Kd andBmax) of [3H]domperidone binding sites measured in the striatum did not show any deviation from control values, but the receptor concentration (Bmax) of [3H]ketanserin binding sites was significantly reduced in the cerebral cortex of lithium-treated rats. The apparent dissociation constant (Kd) was not changed. The results indicate that the serotonergic component of the [3H]spiperone binding site, which we had previously found to be affected by chronic lithium treatment and which was shown by Peroutka and Snyder (1) to be the 5-HT2 receptor, is selectively affected by lithium.

Keywords

Cerebral Cortex Ketanserin Domperidone Lithium Treatment Dopaminergic Receptor 

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Isabel J. Wajda
    • 1
  • Miriam Banay-Schwartz
    • 1
  • Isaac Manigault
    • 1
  • Abel Lajtha
    • 1
  1. 1.Center for NeurochemistryThe Nathan S. Kline Institute for Psychiatric ResearchNew York

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