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How peptidergic neurons cope with variation in physiological stimulation

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Abstract

A general scheme for neuropeptide metabolism is outlined and the potential sites of regulation are discussed. Two major sites of regulation are distinguished: transcription which ultimately limits the rate of translation to form the prepropeptide, and post-translational processing steps. The consequences of up-regulation of these steps in response to increased metabolic demand are discussed. An alternative strategy for peptidergic neurons, reliance on a large pool of neuropeptide, is proposed. Data on the response of enkephalin-containing cell to increased levels of stimulation are reviewed. It is concluded that there is good evidence for genomic up-regulation, perhaps in association with regulation of processing. Evidence based on studies on enkephalin-containing amacrine cells in the chicken retina is also reviewed. It is suggested that these cells rely on a large pool of neuropeptide to cope with changes in demand.

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Authors and Affiliations

  1. Visual Sciences Group, Research School of Biological Sciences and Centre for Visual Sciences, Australian National University, 2601, Canberra, Act, Australia

    I. G. Morgan

  2. Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, 2601, Canberra, Act, Australia

    I. W. Chubb

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  1. I. G. Morgan
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Special issue dedicated to Dr. Lawrence Austin.

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Morgan, I.G., Chubb, I.W. How peptidergic neurons cope with variation in physiological stimulation. Neurochem Res 16, 705–714 (1991). https://doi.org/10.1007/BF00965559

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