Neurochemical Research

, Volume 11, Issue 5, pp 671–685 | Cite as

Effect of chronic valproate treatment on folate-dependent methyl biosynthesis in the rat

  • G. F. Carl
Original Articles


Folate deficency has been associated with chronic anticonvulsant therapy. Characterization of the effects of individual anticonvulsants has been undertaken. Chronic treatmennt of rats with sodium valproate caused a decrease in liver folate concentration with concomitant increases in brain and plasma folate concentrations. After several weeks, these trends were reversed and folate concentrations tended to normalize. Chronic valproate treatment affected the activities of folatedependent one-carbon enzymes: Serine hydroxymethyltransferase activity in liver was increased; methylenetetrahydrofolate reductase activity in both brain and liver was decreased; and methyltetrahydrofolate: homocysteine methyltransfrase activity in both brain and liver decreased initially but returned toward normal with continued treatment. Methionine adenosyltransferase activity in brain declined after several weeks of treatment but the concentration of S-adenosylmethionine in liver increased with chronic valproate treatment. These data are consistent with the hypothesis that the effects of anticonvulsants on folates are a consequence of the mechanism of action of the anticonvulsant.


Folate Methionine Homocysteine Valproate Reductase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



serine hydroxymethyltransferase


methiuonine adenosyltransferase


methyltetrahydrofolate: homocysteine methyltransferase


methylenetetrahydrofolate reductase




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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • G. F. Carl
    • 1
    • 2
  1. 1.Research Service (151)VA Medical CenterAugusta
  2. 2.Departments of Neurology and Medicine (Nutrition)Medical College of GeorgiaAugusta

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