Genotypic differences in age and chronic alcohol exposure effects on somatostatin levels in hippocampus and striatum in mice
- 19 Downloads
Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in reactivity of this neuropeptide to aging processes and chronic alcohol exposure were demonstrated. The Balb/c strain exhibits a significant age dependent decrease in striatal and hippocampal somatostatin levels whereas the C57B1 mice remain unchanged until the 27 month. Moreover, only the Balb/c strain reacts to chronic alcohol exposure, showing a significant increase in somatostatin levels in those structures affected by the aging process. Such genotypic differences may be involved in man in specific pathologies in aged individuals and in alcohol induced behavioral alterations in alcoholics.
KeywordsAging Process Genotypic Variation Inbred Strain Alcohol Exposure Genotypic Difference
Unable to display preview. Download preview PDF.
- 2.Besnard, F., Kempf, E., Fuhrmann, G., andEbel, A. Influence of mouse genotype on responses of central biogenic amines to alcohol intoxication and aging. Submitted.Google Scholar
- 3.Birren, J. E., Woods, A. M., andWilliams, M. V. 1979. Speed of behavior as an indicator of age changes and the integrity of the nervous system. Pages 10–44,in Hoffmeister F., andMuller, C. (eds), Brain Function in Old Age, Bayer Symposium VII, Springer-Verlag, Berlin, Heidelberg, New York.Google Scholar
- 6.Davis, K. L., Hollister, L. E., andBerger, P. A. 1970. Treatment of Huntington's disease and tardive dyskinesia with choline chloride, Pages 87–97,in Davis K. L. andBerger P. A. (eds), Brain Acetylcholine and Neuropsychiatric Disease, Plenum Press, New York.Google Scholar
- 8.Durkin, T. P., Hashem-Zadeh, H., Mandel, P., andEbel, A. 1981. A comparative study of the acute effects of ethanol on the cholinergic system in hippocampus and striatum of inbred mouse strains. J. Pharmacol. Exp. Ther. 220:203–208.Google Scholar
- 12.Fuhrmann, G., Di Scala-Guenot, D., Strosser, M. T., Kempf, E., Kempf, J., andEbel, A. 1984. Neuromodulatory effects of somatostatin on striatal and hippocampal cholinergic activity in mice—behavioural incidences. European Brain and Behaviour Society, Annual Meeting (2–5 septembre 1984), Strasbourg, France.Google Scholar
- 13.Hornykiewicz, O. 1983. Parkinson's disease and the aging basal ganglia, Pages 253–274,in Gispen W. H., andTraber, J. (eds), Aging of the Brain, Vol. 7, Elsevier Science Publisher, Amsterdam.Google Scholar
- 14.Isaacson, R. L., andHannigan, J. H. 1983. The hippocampus and age-related disorders. Pages 139–148,in Gipsen, W. H. andTraber, J. (eds), Aging of the Brain, vol. 7, Elsevier Science Publisher, Amsterdam.Google Scholar
- 16.Kempf, E., Fuhrmann, G., andEbel, A. 1985. Genotypic variations in ethanol effects on striatal and hippocampal transmitter interactions. Alcohol, 3:231–237.Google Scholar
- 22.Rossor, M. N. 1982. Neurotransmitters and CNS disease: Dementia. The Lancet II, 1200–1204.Google Scholar
- 23.Samuel, D., Heron, D. S., Herschkowitz, M., andShinikky, M. 1982. Aging, receptor binding and membrane microviscosity. Pages 93–105,in Giacobini, E., Filogamo, G., Giacobini, G., andVernadakis, A. (eds.) The Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System, Raven Press, New York.Google Scholar
- 26.Trabucchi, M., Spano, P. F., Govoni, S., Riccardi, F., andBosio, A. 1982. Dopaminergic function during aging in rat brain. Pages 195–201,in Giacobini, E., Filogamo, G., Giacobini, G., andVernadakis, A. (eds), The Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System, Raven Press, New York.Google Scholar