Neurochemical Research

, Volume 11, Issue 4, pp 497–504 | Cite as

Somatostatin effects on the cyclic AMP system and lipid metabolism in mouse brain

  • R. E. Catalan
  • A. M. Martinez
  • B. G. Miguel
  • A. Robles
  • M. D. Aragones
Original Articles

Abstract

The effect of somatostatin on cyclic AMP-protein kinase system and lipid metabolism was studied in mouse brain. Subcutaneous injection of the peptide decreased the cyclic AMP and cyclic GMP levels (70% and 60% respectively) as well as protein kinase and triglyceride lipase activities (30%). Cyclic AMP binding protein activity was not affected. Experiments carried out with [14C]acetate as precursor of lipids seem to indicate that somatostatin blocks the fatty acid turnover. On the other hand, the general decrease of32P incorporation into all phospholipids by somatostatin suggests that the peptide interferes with the precursor uptake into phospholipids. The findings reported here indicate that somatostatin has a role on brain metabolism and further add more data in support for its neuromodulating action.

Keywords

Lipase Triglyceride Lipase Kinase System Binding Protein Activity Neuromodulating Action 

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • R. E. Catalan
    • 1
  • A. M. Martinez
    • 2
  • B. G. Miguel
    • 2
  • A. Robles
    • 2
  • M. D. Aragones
    • 2
  1. 1.Departamento de Bioquímica y Biología Molecular Centro de Biología Molecular (CSIC-UAM)Universidad Autónoma de MadridMadridSpain
  2. 2.Departamento de Bioquímica Facultad de CienciasUniversidad ComplutenseMadridSpain

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