Neurochemical Research

, Volume 11, Issue 6, pp 769–787 | Cite as

Neuroendocrine heart and hypothalamus

  • Armen Galoyan
An Overview

Abstract

Data on the endocrine heart—neurosecretory cells of heart, producing coronarydilatory, metabolically active glycopeptides with physico-chemical and biological properties similar to those of previously discovered cardioactive hypothalamic neurohormones—are summarized. Heart hormones participate in both local and distant regulation of heart metabolism and function. Formation and action of these heart hormones is closely related to hypothalamic cardioactive neurohormones K, C, and G and their protein precursors. Neurohormones from heart and hypothalamus comprise a system of neurohumoral connections between these two organs. A possible role of APUD cells in the generation of a number of heart peptides and glycopeptides exerting hormonal activity is discussed.

Keywords

Peptide Biological Property Protein Precursor Glycopeptide Distant Regulation 

Abbreviations Used

NC

Neurohormone C

NK

Neurohormone K

NC-H

Hypothalamic NC

NK-H

Hypothalamic NK

PC-NC

NC cleaved from protein-carrier

PC-NK

NK cleaved from protein-carrier

BB-NC

Brain blood NC

BB-NK

Brain blood NK

H1

Substrate 1 from heart

H2

Substrate 2 from heart

H3

Substrate 3 from heart

HB1

Substrate 1 from heart blood

HB2

Substrate 2 from heart blood

PC-H1

H1 cleaved from protein-carrier

PC-H2

H2 cleaved from protein-carrier

PC-H3

H3 cleaved from protein-carrier

PC-CC

Coronaroconstrictory substance cleaved from protein-carrier

GPG

Gomori-positive granules

MLC

Mast-like cells

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Galoyan, A. A. 1962. Acad. Sci. ArmSSR 34:109–111.Google Scholar
  2. 2.
    Galoyan, A. A. 1963. Izvestia Acad. Sci. ArmSSR 16:3–18.Google Scholar
  3. 3.
    Galoyan, A. A. 1973. Voprosi Biochim Mozga 8:107–125.Google Scholar
  4. 4.
    Galoyan, A. A. 1979. Voprosi Biochim. Mozga 13:9–38.Google Scholar
  5. 5.
    Galoyan, A. A. 1964. Dokl. Acad. Sci., ArmSSR 38:305–308.Google Scholar
  6. 6.
    Galoyan, A. A., andSrapionian.,R. M. 1983 Neurochem. Res. 8:1511–1535.Google Scholar
  7. 7.
    Galoyan, A. A., Azaryan, A. V., andBarchudarian, N. A. 1984. Pages 229–236. Proc. of the V-th Meeting of ESN, Akademiai Kiado Press, Hungary.Google Scholar
  8. 8.
    Galoyan, A. A 1963. Regulation of Neurosecretion and the Hormones of Hypothalamo-Neurohypophyseal System. Yerevan, Doctorate dissert.Google Scholar
  9. 9.
    Galoyan, A. A. 1964. The Problems of Endocrinology and Hormonotherapy 3:111–118.Google Scholar
  10. 10.
    Galoyan, A. A. 1965. Some Problems of Biochemistry of Hypothalamic Regulation, “Hajastan” Press, Yerevan, monography.Google Scholar
  11. 11.
    Srapionian R. M., Sahakian, S. A., Sahakian, F. M., andGaloyan, A. A. 1979. Vopr. Biokhim. Mozga 13:67–78.Google Scholar
  12. 12.
    Srapionian, R. M., Jambazian, T. A., andGaloyan, A. A. 1970. Vopr. Biokhim. Mozga 6:157–160.Google Scholar
  13. 13.
    Galoyan, A. A., Gurvitz, B. Y., andPogosian, M. A., 1976. Vopr. Biokhim. Mozga 9:89–96.Google Scholar
  14. 14.
    Galoyan, A. A., andGurvitz, B. Y. 1977. Dokl. Acad. Sci. ArmSSR 65:173–180.Google Scholar
  15. 15.
    Galoyan, A. A., Gurvitz, B. Y., Saribekian, G. A., andKirakosova, A. S. 1979. Pages 165–181in Cehovic, G., andRobison, G. (eds.) Cyclic Nucleotides and Therapeutic Perspectives. Pergamon Press.Google Scholar
  16. 16.
    Misirian, S. S., Srapionian, R. M., Bkheian, M. B., Saribekian, G. A., andGaloyan, A. A. 1979. Biol. J. Armenii 32:397–401.Google Scholar
  17. 17.
    Galoyan, A. A., andGurvitz, B. Y. 1982. Vestnik Acad. Med. Sci. USSR 9:64–69.Google Scholar
  18. 18.
    Galoyan, A. A., andRostomian, M. A. 1967. Biol. J. Armenii 20:3–9.Google Scholar
  19. 19.
    Rostomian, M. A., andGaloyan, A. A. 1971. Biol. J. Armenii 24:24–30.Google Scholar
  20. 20.
    Abrahamina, S. S., andGaloyan, A. A. 1982. Biol. J. Armenii 35:606–611.Google Scholar
  21. 21.
    Abrahamian, S. S. andGaloyan, A. A. 1983. Biol. J. Armenii 35:92–96.Google Scholar
  22. 22.
    Galoyan, A. A. 1973. Page 71 in the Proceedings of the II-nd All-Union Meeting of Cardiologs, Moscow.Google Scholar
  23. 23.
    Srapionian, R. M., andGaloyan, A. A. 1973. Dokl. Acad. Sci. ArmSSR 56:174–177.Google Scholar
  24. 24.
    Misirian, S. S., Srapionian, R. M., Medvedev, F. A., andGaloyan, A. A. 1979. Dokl. Acad. Sci. ArmSSR 69:290–294.Google Scholar
  25. 25.
    Misirian, S. S., Srapionian, R. M., Sarkisian, R.SH., Karapetian, R. H., andGaloyan, A. A. 1979. Biol. J. Armenii 35:706–709.Google Scholar
  26. 26.
    Misirian, S. S., Abelian, J. G., Srapionian, R. M., andGaloyan, A. A. 1979. Biol. J. Armenii 32:470–472.Google Scholar
  27. 27.
    Galoyan, A. A. 1978. Ergebnisse der Experimentallen Medizin 29:99–115.Google Scholar
  28. 28.
    Galoyan, A. A., andAlexanian, R. A. 1963. Dokl. Acad. Sci. ArmSSR 37:157–160.Google Scholar
  29. 29.
    Mikaelian, A. L., Galoyan, A. A., Sherdukalova, L. F., Manasian, L. A., andAdamian, K. G. 1973. Dokl. Acad. Sci. ArmSSR 57:58–63.Google Scholar
  30. 30.
    Parsadanian, G. K., Abelian, J. G., andGaloyan, A. A. 1978. Dokl. Acad. Sci. ArmSSR 64:164–167.Google Scholar
  31. 31.
    Galoyan, A. A., Ohanian, M. V., andGevorkian, G. G. 1971. Dokl. Acad. Sci. ArmSSR 53:254–256.Google Scholar
  32. 32.
    Ohanian, M. V., Galoyan, A. A., andKarapetian, R. H. 1972. Biol. J. Armenii 25:17–20.Google Scholar
  33. 33.
    Srapionian, R. M., andGaloyan, A. A. 1973. Dokl. Acad. Sci. ArmSSR 56:174–177.Google Scholar
  34. 34.
    Srapionian, R. M., Misirian, S. S., andGaloyan, A. A. 1975. Vopr. Biochim. Mozga 10:122–128.Google Scholar
  35. 35.
    Galoyan, A. A., Srapionian, R. M., andMedvedev, F. A. 1978. Dokl. Acad. Sci. ArmSSR 66:302–306.Google Scholar
  36. 36.
    Bompiani, G. D., Rouiller, C., andHatt, R. Y. 1959. Arch. Mal. Coeur Vaiss 52: 1257–1262.Google Scholar
  37. 37.
    Jamieson, J. D., andPalade, G. E. 1964. J. Cell. Biol. 23:151–172.Google Scholar
  38. 38.
    Palade, C. E. 1961. Anat. Res. 139:262.Google Scholar
  39. 39.
    De Bold, A. 1979. Proc. Soc. Exp. Biol. Med. 170:133–138.Google Scholar
  40. 40.
    De Bold, A., Borenstein, H. B., Veress, A. T., andSonnenberg, H. 1981. Life Sci. 28:89–94.Google Scholar
  41. 41.
    Currie, M. G., Geller, D. M., Cole, B. R., Boylan, J. G., Yusheng, W., Holmberg, S. W., andNeedelman, P. 1983. Science 221:71–73.Google Scholar
  42. 42.
    Flynn, T. G., De Bold, M. L., andDe Bold, A. V. 1983. Biochem. Biophys. Res. Commun. 117:859–865.Google Scholar
  43. 43.
    Geller, D. M., Currie, M. G., Wakitani, K., Cole, B. R., Adams, S. P., Fok, K. F., Siegel, N. R., Galluppi, G. R., andNeedelman, P. 1984. Biochem. Biophys. Res. Commun. 120:333–338.Google Scholar
  44. 44.
    Atlas, S. A., Klrinert, H. D., Camargo, M. S., Januszcwicz, A., Sealey, N. E., Laragh, J. H., Shilling, J. W., Lewick, J. A., Johnson, L. K., andMaack, T. 1984. Nature 309:717–719.Google Scholar
  45. 45.
    Kangawa, K., andMatsuo, H 1984. Biochem. Biophys. Res. Commun. 118:131–139.Google Scholar
  46. 46.
    Kennedy, B. P., Marsden, J. J., Flynn, T. G., De Bold, A. J., andDavies, P. L. 1984. Biochem. Biophys. Res. Commun. 122:1076–1082.Google Scholar
  47. 47.
    Seidman, C. E., Duby, A. D., Choi, E., Graham, R. M., Haber, E., Homcy, C., Smith, J. A., andSeidman J. A. 1984. Science 225:324–326.Google Scholar
  48. 48.
    Yamanaka, M., Greenberg, B., Johnson, L., Seilhamer, J., Brewer, M., Friedemann, T., Muller, J., Atlas, S., Laragh, J., Zeweiki, N., andFiddes, J., 1984. Nature 309:719–724.Google Scholar
  49. 49.
    Nakayama, K., Ohkubo, H., Hirose, T., Inayama, S., andNakamashi, S., 1984. Nature 310:699–701.Google Scholar
  50. 50.
    Tanaka, J., Misono, K. C., andInagami, T. 1984. Biochem. Biophys. Res. Commun. 124:663–668.Google Scholar
  51. 51.
    Jacobowitz, D. M., Skofitsch, G., Keiser, H. R., Skuy, R. Z., andZamiz, N. 1985. Neuroendocrinology 40:92–103.Google Scholar
  52. 52.
    Tremblay, J., Gerrer, R., Vinay, P., Pang, S. C., Beliveau, andHamet, P. 1985. FEBS Letters 181:17–22.Google Scholar
  53. 53.
    Napier, M. A. et al., 1984. Proc. Natl. Acad. Sci. USA 81:5946–5950.Google Scholar
  54. 54.
    Sonnenberg, H., andVaress, A. T. 1984. Biochem. Biophys. Res. Commun. 124:443–449.Google Scholar
  55. 55.
    Yunge, L., Ballak, M., Beuzeron, J., Lacasse, J., andCantin, M. 1980. Can. J. Physiol. Pharmacol. 58:1463–1476.Google Scholar
  56. 56.
    Cantin, M., Gutkowska, J., Thibault, G., Milne, R. W., Ledoux, S. et al. 1984 Histochemistry 80:113–127.Google Scholar
  57. 57.
    Forssman, W. G., Hock, D. et al. 1983. Anat. and Embryol. 168:307–313.Google Scholar
  58. 58.
    Hickling, M. Y.. et al. 1976. Experientia 32:554–555.Google Scholar
  59. 59.
    Pearse, A. G. 1968. Proc. Roy. Soc.B. 170:71–80.Google Scholar
  60. 60.
    Pearse, A. G. 1969. J. Histochem. and Cytochem. 17:303–313.Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Armen Galoyan
    • 1
  1. 1.Institute of BiochemistryYerevanUSSR

Personalised recommendations