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Neurochemical Research

, Volume 7, Issue 12, pp 1445–1452 | Cite as

Retinal pigment epithelium contains a distinctive strychnine-binding site

  • Stephen C. Bondy
  • John M. Werdel
  • R. Theodore Fletcher
  • Gerald J. Chader
Original Articles

Abstract

Membranes prepared from the retinal pigment epithelium of several species possess a specific site which binds [3H]strychnine. This binding has a somewhat lower affinity and a much greater density than the corresponding interaction in the hindbrain or neural retina. Binding is not greatly altered in the presence of 10−3 M glycine,l-alanine, β-alanine, taurine, or serine. Thus, the receptor does not resemble the classical glycine receptor of the hindbrain and spinal cord. This new type of binding site appears to be confined to the pigment epithelial layer of the retina.

Keywords

Spinal Cord Glycine Retina Serine Taurine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Stephen C. Bondy
    • 1
  • John M. Werdel
    • 1
  • R. Theodore Fletcher
    • 2
  • Gerald J. Chader
    • 2
  1. 1.Laboratory of Behavioral and Neurological ToxicologyNational Institute of Environmental Health SciencesResearch Triangle Park
  2. 2.Laboratory of Vision Research National Eye InstituteNational Institutes of HealthBethesda

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