Neurochemical Research

, Volume 7, Issue 1, pp 115–124 | Cite as

The dopamine receptor adenylate cyclase complex: Evidence for post recognition site involvement for the development of supersensitivity

  • M. Parenti
  • S. Gentleman
  • M. C. Olianas
  • N. H. Neff
Original Articles

Abstract

The dopamine receptor adenylate cyclase complex of a rat striatal membrane preparation became more responsive to dopamine following the injection of 6-hydroxydopamine (6-OHDA) into the median forebrain bundle or following the subcutaneous implantation of morphine pellets. Moreover, the membrane cyclase system was more responsive to activation by GTP, guanyl-5′-yl-imidodiphosphate and Mn-ATP. These observations suggest that both 6-OHDA and morphine induce similar biochemical changes in striatum and that the increased responsiveness arises, in part, from modification of the nucleotide regulatory and/or catalytic components of adenylate cyclase.

Keywords

Nucleotide Dopamine Morphine Adenylate Cyclase Recognition Site 

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • M. Parenti
    • 1
  • S. Gentleman
    • 1
  • M. C. Olianas
    • 1
  • N. H. Neff
    • 1
  1. 1.Laboratory of Preclinical Pharmacology National Institute of Mental HealthSaint Elizabeths HospitalWashington, D.C.

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