Neurochemical Research

, Volume 6, Issue 9, pp 969–977 | Cite as

Tissue specificity of dopamine effects on brain ATPases

  • M. Antonelli de Lima Gómez
  • G. Rodríguez de Lores Arnaiz
Original Articles


Dopamine inhibits Mg2+,Na+,K+- and Na+,K+-ATPase activities but does not modify Mg2+-ATPase activity of nerve ending membranes isolated from rat cerebral cortex. In the presence of the soluble fraction of brain, dopamine activates total, Na+,K+-, and Mg2+-ATPases. Dopamine stimulation of nerve ending membrane ATPases is achieved when soluble fractions of brain, kidney, or liver are used. On the other hand, dopamine effects are not observed on kidney or heart ATPase preparations. These results indicate tissue specificity of dopamine effects with respect to the enzyme source; there is no tissue specificity for the requirement of the soluble fraction to achieve stimulation of ATPases by dopamine.


Dopamine Cerebral Cortex ATPase Activity Soluble Fraction Tissue Specificity 
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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • M. Antonelli de Lima Gómez
    • 1
  • G. Rodríguez de Lores Arnaiz
    • 1
  1. 1.Instituto de Biología Celular Facultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

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