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On the mechanism of fasting-associated elevations in hypothalamic cyclo(His-Pro) content

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Abstract

Potential mechanism(s) underlying the fasting-associated rise in hypothalamic cyclo(His-Pro) content was explored by examining the effects of 24-hour fasting on: (i) cyclo(His-Pro) synthesis from TRH, (ii) cyclo(His-Pro) metabolism, and (iii) cyclo (His-Pro) secretion by hypothalamic tissue in vitro. The data presented here show that none of these three variables were altered due to fasting. Two additional potential changes that could cause cyclo(His-Pro) elevations during fasting are suggested. These include an in vivo decrease in hypothalamic cyclo(His-Pro) secretion that may not be apparent in vitro, and/or an increase in the synthesis of cyclo(His-Pro) from a precursor(s) other than TRH.

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Authors and Affiliations

  1. Department of Medicine (Section of Endocrinology), Louisiana State University Medical Center, 1542 Tulane Avenue, 70112, New Orleans, LA

    Chandan Prasad, Tokuji Iriuchijima, Ruth M. Edwards, John F. Wilber, Masatomo Mori & Deborah J. Rogers

  2. Department of Biochemistry, Louisiana State University Medical Center, 1542 Tulane Avenue, 70112, New Orleans, LA

    Chandan Prasad

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  1. Chandan Prasad
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  2. Tokuji Iriuchijima
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  3. Ruth M. Edwards
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  4. John F. Wilber
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  5. Masatomo Mori
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  6. Deborah J. Rogers
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Prasad, C., Iriuchijima, T., Edwards, R.M. et al. On the mechanism of fasting-associated elevations in hypothalamic cyclo(His-Pro) content. Neurochem Res 11, 339–347 (1986). https://doi.org/10.1007/BF00965008

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  • DOI: https://doi.org/10.1007/BF00965008

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