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Neurochemical Research

, Volume 14, Issue 8, pp 761–764 | Cite as

Modulation of ATPase activities in the central nervous system by the S-100 proteins

  • Armen Simonian
  • Jacques Baudier
  • Kenneth G. Haglid
Original Articles

Abstract

The isomeric forms of bovine S-100a and S-100b have been shown to stimulate ATPase activities in fractions enriched in myelin and mitochondria isolated from the Gerbil brain and for S-100b more effectively than for calmodulin in erythrocytes or skeletal muscle. In the presence of Ca2+, S-100a produced a slight increase of ATPase activity in the mitochondrial fraction. However, S-100b, with or without Ca2+ and Zn2+ respectively, had no effect on the ATPase activity in mitochondria of the Gerbil liver. The observations may indicate a “second messenger” role for S-100b in the presence of Zn2+ in the Schwann cell.

Key Words

S-100a S-100b Ca2+ Zn2+ ATPase myelin synaptosome Gerbil brain 

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Armen Simonian
    • 1
  • Jacques Baudier
    • 2
  • Kenneth G. Haglid
    • 3
  1. 1.Institute of BiochemistryAcademy of Sciences of Armenian SSRYerevanUSSR
  2. 2.Laboratoire de Physics, ERA, CNRS-551UER des Sciences PharmaceutiquesStrasbourg, CedexFrance
  3. 3.Institute of NeurobiologyUniversity of GöteborgGöteborgSweden

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