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Effects of base exchange reaction on the Na+, K+ ATPase in rat brain microsomes

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Abstract

Incorporation of ethanolamine and monomethylethanolamine into their corresponding phospholipid by the base exchange enzymes activated an Na+, K+-ATPase associated with a rat brain microsomes enriched preparation. The serine and dimethylethanolamine base exchange catalyzed incorporation reactions inhibited this particular Na+, K+-ATPase. These effects require Ca+ and several other structural analogues which are not incorporated into phospholipid were without affect on this ATPase.

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Abbreviations

MME:

monomethylethanolamine

DME:

dimethylethanolamine

EA:

ethanolamine

S:

serine

C:

choline

PMME:

phosphatidyl-mono-methyl-ethanolamine

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Authors and Affiliations

  1. Department of Biochemistry Faculty of Medicine, The University of Manitoba, R3E OW3, Manitoba, Canada

    Hiroshi Hattori & Julian N. Kanfer

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  1. Hiroshi Hattori
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  2. Julian N. Kanfer
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Hattori, H., Kanfer, J.N. Effects of base exchange reaction on the Na+, K+ ATPase in rat brain microsomes. Neurochem Res 8, 1185–1195 (1983). https://doi.org/10.1007/BF00964932

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  • DOI: https://doi.org/10.1007/BF00964932

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