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High affinity uptake of GABA and glycine by rabbits with aluminum-induced neurofibrillary changes

Neurochemical Research volume 8, pages 1097–1109 (1983)Cite this article

Abstract

The high affinity uptake of GABA and glycine by synaptosomal preparations of rabbit hippocampus and spinal cord has been characterized. The high affinity uptake by such preparations from rabbits in which chronic neurofibrillary changes had been induced with aluminum chloride was measured and found to be reduced. The reduction was the greatest when the number of neurons affected was the greatest. These results suggest that normal neurotransmitter function is considerably disturbed in neurons affected with neurofibrillary changes.

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Affiliations

  1. Department of Pathological Biochemistry, Institute for Basic Research in Developmental Disabilities, 10314, Staten Island, New York

    John A. Sturman, Henryk M. Wisniewski & Judy W. Shek

  2. Department of Pathological Neurobiology, Institute for Basic Research in Developmental Disabilities, 10314, Staten Island, New York

    John A. Sturman, Henryk M. Wisniewski & Judy W. Shek

Authors
  1. John A. Sturman
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  2. Henryk M. Wisniewski
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  3. Judy W. Shek
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Sturman, J.A., Wisniewski, H.M. & Shek, J.W. High affinity uptake of GABA and glycine by rabbits with aluminum-induced neurofibrillary changes. Neurochem Res 8, 1097–1109 (1983). https://doi.org/10.1007/BF00964925

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  • DOI: https://doi.org/10.1007/BF00964925

Keywords

  • Aluminum
  • Chloride
  • Spinal Cord
  • Glycine
  • Aluminum Chloride