Neurochemical Research

, Volume 7, Issue 9, pp 1075–1088 | Cite as

DNA content and enzymic activities in the auditory regions of seizuresusceptible and non-susceptible strains of mice

  • D. F. Wheeler
  • N. E. I. R. Contreras
  • H. S. Bachelard
Original Articles

Abstract

The developmental profiles of four glycosidase enzymes (β-D-glucosidase, β-D-glucuronidase, β-D-N-acetylglucosaminidase and β-D-galactosidase) in the cochleas, cochlear nuclei and inferior colliculi of four strains of mice were investigated. The strains used were an audiogenically seizure-susceptible strain (DBA/2) and three non-susceptible strains (BALB/c, C3H/He and Swiss/A2G). The enzymic activities fell to varying degrees from 7 to 28 days of age. Two significant observations were made—β-D-glucuronidase was low in the regions of the C3H/He strain, and β-D-galactosidase was particularly low in the regions of the DBA/2 strain. The very low activity of β-D-galactosidase in the DBA/2 mice is discussed in relation to the ganglioside patterns known to be present in these seizure-susceptible mice. Studies on the DNA contents of these auditory regions in the four strains showed no correlation with seizure sensitivity.

Keywords

Enzymic Activity Inferior Colliculus Cochlear Nucleus Significant Observation Developmental Profile 

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • D. F. Wheeler
    • 1
  • N. E. I. R. Contreras
    • 1
  • H. S. Bachelard
    • 1
  1. 1.Department of BiochemistrySt. Thomas's Hospital Medical SchoolLondonUK

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