Neurochemical Research

, Volume 5, Issue 6, pp 605–616 | Cite as

Effect of inorganic lead exposure on myelination in the rat

  • Arrel D. Toews
  • Martin R. Krigman
  • David J. Thomas
  • Pierre Morell
Original Articles

Abstract

The effect of defined lead burdens on myelination of the central and peripheral nervous systems was studied in neonatal Long-Evans rats. Pups were exposed to inorganic lead (100 or 400 mg Pb as lead acetate/kg body wt/day by gastric intubation) from day 2 following birth to 30 days of age. Accumulation of myelin in forebrain was not affected by the 100-mg dosage, but at the 400 mg/kg dosage level, myelin accumulation was reduced by approximately 42% on a per gram forebrain basis relative to vehicle-intubated animals. The deficit was over 50% on a per forebrain basis, since there was also a slight reduction in brain weight. This lead effect was observed at both 15 and 30 days of age. Accumulation of myelin in optic nerve (determined on the basis of proteolipid protein concentration) was also reduced by 30% relative to controls by this dosage level. However, myelination in sciatic nerve (determined on the basis of P0 protein concentration) was not affected by this exposure regimen. Myelin deficits were greater than could be accounted for by undernutrition arising secondary to lead exposure and were not due to a developmental delay in the onset of myelination.

Keywords

Optic Nerve Dosage Level Sciatic Nerve Developmental Delay Peripheral Nervous System 

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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Arrel D. Toews
    • 1
    • 2
    • 3
  • Martin R. Krigman
    • 1
    • 2
    • 3
  • David J. Thomas
    • 1
    • 2
    • 3
  • Pierre Morell
    • 1
    • 2
    • 3
  1. 1.Department of Biochemistry and NutritionUniversity of North Carolina at Chapel HillChapel Hill
  2. 2.Department of PathologyUniversity of North Carolina at Chapel HillChapel Hill
  3. 3.Biological Sciences Research Center-22OHUniversity of North Carolina at Chapel HillChapel Hill

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