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Neurochemical Research

, Volume 9, Issue 10, pp 1431–1443 | Cite as

Degradation of bovine P2 protein by bovine brain cathepsin D

  • John N. Whitaker
  • Jerome M. Seyer
Article

Abstract

Bovine brain cathepsin D cleaved bovine P2 protein to produce three major and several minor peptides. The major P2 peptides formed were shown by amino acid analysis and partial sequencing to be peptides 17–54, 20–58 and 65–131 with the latter predominating. In preliminary experiments, P2 peptide 65–131 did not induce experimental allergic neuritis in Lewis rats in equimolar amounts to the neuritogenic P2.

Keywords

Peptide Partial Sequencing Equimolar Amount Amino Acid Analysis Neuritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • John N. Whitaker
    • 1
    • 2
    • 3
    • 4
  • Jerome M. Seyer
    • 1
    • 5
  1. 1.Research Service of the Memphis Veterans Medical CenterMemphis
  2. 2.Neurology Service of the Memphis Veterans Medical CenterMemphis
  3. 3.Department of Neurology of the University of TennesseeCenter for the Health SciencesMemphis
  4. 4.Department of Anatomy of the University of TennesseeCenter for the Health SciencesMemphis
  5. 5.Department of Biochemistry of the University of TennesseeCenter for the Health SciencesMemphis

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