Neurochemical Research

, Volume 10, Issue 2, pp 283–295 | Cite as

The effects of lubrol WX on brain membrane Ca2+/Mg2+ ATPase and ATP-dependent Ca2+ uptake activity following acute and chronic ethanol

  • D. H. Ross
  • K. M. Garrett
  • H. L. Cardenas
Original Articles


  1. 1.

    Acute administration of ethanol (2.5 gm/kg, i.p.) to rats inhibits the cytosolic buffering of Ca2+ in nerve terminals.

  2. 2.

    Ca2+ ATPase and ATP-dependent Ca2+ uptake are both inhibited 30 min after a single dose of ethanol.

  3. 3.

    Chronic ethanol administration (6%, 14 days) did not inhibit Ca2+ ATPase but significantly stimulated ATP-dependent Ca2+ uptake.

  4. 4.

    Lubrol WX treatment of acute ethanolicmembranes reverses the inhibition of Ca2+ ATPase seen following ethanol.

  5. 5.

    Lubrol WX treatment of chronic ethanolic membranes prevents the increase in ATP-dependent Ca2+ uptake seen in ethanolic membranes.

  6. 6.

    Both acute and chronic ethanol-induced changes in Ca2+ transport within nerve teminals may involve lipid-dependent parameters of the membrane which may underlie neuronal adaptation.



Single Dose Nerve Terminal Acute Administration Uptake Activity Chronic Ethanol 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • D. H. Ross
    • 1
  • K. M. Garrett
    • 1
  • H. L. Cardenas
    • 1
  1. 1.Division of Molecular PharmacologyThe University of Texas Health Science CenterSan Antonio

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