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Localization and heterogeneity of central benzodiazepine receptors

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References

  1. Langer, S. Z. 1977. Presynaptic receptors and their role in the regulation of transmitter release. J. Pharmacol. 60:481.

    Google Scholar 

  2. Braestrup, C., andNielsen, M. 1980. Searching for endogenous benzodiazepine receptor ligands. Trends Pharmacol Sci.: 424–427.

  3. Lo, M. M. S., Niehoff, D. L., Kuhar, M. L., andSnyder, S. H. 1983. Differential localization of type I and type II benzodiazepine sites in substantia nigra. Nature 306:57–60.

    PubMed  Google Scholar 

  4. Gallager, D. M., Mallorga, P., Oertel, W., Henneberry, R., andTallman, J. 1981.3H-Diazepam binding in mammalian central nervous system: A pharmacological characterization. J Neurosci. 1:218–225.

    PubMed  Google Scholar 

  5. Sábato, U. C., Aguilar, J. S., andDe Robertis, E. 1981. Benzodiazepine receptors in rat brain: action of Triton X-100 localization in relation to the synaptic region. J. Receptor Res. 2:119–133.

    Google Scholar 

  6. Möhler, H. Richards, J. G., andWu, J. Y. 1981. Autoradiographic localization of benzodiazepine receptors in immunocytochemically identified γ-aminobutyrergic synapses. Proc. Natl. Acad. Sci. USA, 78:1935–1938.

    PubMed  Google Scholar 

  7. De Robertis, E., Azcurra, J., andFiszer, S. 1967. Ultrastructure and cholinergic binding capacity of junctional complexes isolated from rat brain. Brain Res. 5:45–56.

    Google Scholar 

  8. Cotman, C. W. andTaylor, D. 1972) Isolation and structural studies on synaptic complexes from rat brain. J. Cell Biol. 55:696–711.

    PubMed  Google Scholar 

  9. Cohen, R. S. Blomberg, F., Berzins, K., andSiekevitz, P. 1977. The structure of postsynaptic densities isolated from dog cerebral cortex. J. Cell Biol. 74:181–203.

    PubMed  Google Scholar 

  10. Jimenez Aguilar, C., andDe Robertis E. 1982. Dopaminergic receptors in cat brain. Action of Triton X-100 on3H-spiroperidol binding and localization in relation to the synaptic region. Eur. J. Pharmacol. 79:1–9.

    PubMed  Google Scholar 

  11. Aguilar, J. S., Criado, M., andDe Robertis, E., 1979. Pre- and postsynaptic localization of central muscarinic receptors. Eur. J. Pharmacol. 5:227–230.

    Google Scholar 

  12. Sábato, U. C., Aguilar, J. S., Medina, J. H. andDe Robertis, E. 1981. Changes in rat hippocampal benzodiazepine receptor and lack of changes in muscarinic receptors after fimbria-fornix lesions. Neurosci. Lett. 27:193–197.

    PubMed  Google Scholar 

  13. Overstreet, D. H., Speth, R. C., Hruska, R. E., Ehlert, F., Dumont, Y., andYamamura, H. I. 1980. Failure of septal lesions to alter muscarinic cholinergic or benzodiazepine binding sites in hippocampus of rat brain. Brain Res. 195:203–207.

    PubMed  Google Scholar 

  14. Sábato, U. C., Novas, M. L., Lowenstein, P., Zieher, L. M., andDe Robertis, E. 1981. Action of 6-hydroxydopamine on benzodiazepine receptors in rat cerebral cortex. Eur. J. Pharmacol. 73:381–382.

    Google Scholar 

  15. Doble, A., Iversen, L. L., Bowery, N. G., Hill, D. R., andHudson, A. 1981. 6-Hydroxydopamine decreases benzodiazepine but not GABA receptor binding in rat cerebellum. Neurosci. Lett. 27:199–204.

    PubMed  Google Scholar 

  16. Novas, M. L., Medina, J. H., andDe Robertis, E. 1983. Benzodiazepine receptors in the rat hippocampal formation: action of catecholaminergic, serotoninergic and commissural denervation. Neuroscience 8:459–463.

    PubMed  Google Scholar 

  17. Medina, J. H., andNovas, M. L. 1983. Parallel changes in brain flunitrazepam binding and density of noradrenergic innervation. Eur. J. Pharmacol. 88:377–382.

    PubMed  Google Scholar 

  18. Redmond Jr., D. E., andHuang, Y. H. 1979. New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sci. 25:2149–2162.

    PubMed  Google Scholar 

  19. Nielsen, M., andBraestrup, C. 1980. Ethyl-β-carboline-3-carboxylate shows differential benzodiazepine receptor interaction. Nature, Lond. 286:606–607.

    Google Scholar 

  20. Medina, J. H., Novas, M. L., andDe Robertis, E. 1983. Heterogeneity of Benzodiazepine receptors: experimental differences between3H flunitrazepam and [3H]ethyl-β-carboline-3-carboxylate binding sites in rat brain membranes. J. Neurochem. 41:703–709.

    PubMed  Google Scholar 

  21. Squires, R. F. 1983. Benzodiazepine receptor multiplicity. Neuropharmacology 22:1443–1450.

    PubMed  Google Scholar 

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De Robertis, E., Medina, J.H. Localization and heterogeneity of central benzodiazepine receptors. Neurochem Res 10, 857–863 (1985). https://doi.org/10.1007/BF00964542

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