Neurochemical Research

, Volume 9, Issue 7, pp 863–869 | Cite as

Status of cholinesterase activities in blood in neuropsychiatric disorders

  • Stephen I. Deutsch
  • Magda Campbell
An Overview


The availability of easily accessible biochemical trait markers of central cholinergic activity would assist in the identification of homogeneous subgroups of neuropsychiatric patients within specific diagnostic categories. In addition to a refinement of nosology, these measures could also help to design specific treatment interventions. The activities of cholinesterase isoenzymes in blood have been reported to be abnormal in neuropsychiatric disorders with proven or hypothesized abnormalities of central cholinergic transmission. However, the relevance of these peripheral cholinesterase abnormalities to disordered central cholinergic transmission remains uncertain. Future studies examining specific cholinesterase isoenzymes in homogeneous diagnostic groups are needed to determine the potential utility of these measures as peripheral trait markers of central cholinergic activity.


Future Study Specific Treatment Cholinesterase Potential Utility Diagnostic Category 
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  1. 1.
    Davis, K. L., andBerger, P. A. 1978. Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. Biol. Psychiat. 13:23–49.PubMedGoogle Scholar
  2. 2.
    Davis, K. L. 1979. Cholinomimetic treatment of neuropsychiatric disorders: a review of recent developments. Mt. Sinai J. Med. 46:455–459.PubMedGoogle Scholar
  3. 3.
    Davies, P., andMaloney, A. J. F. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403.Google Scholar
  4. 4.
    Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., andDeLong, M. R. 1981. Alzheimer disease: evidence for selectived loss of cholinergic neurons in the nucleus basalis. Ann. Neurology 10:122–126.Google Scholar
  5. 5.
    Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., andDeLong, M. R. 1982. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237–1239.PubMedGoogle Scholar
  6. 6.
    Johns, C. A., Greenwald, B. S., Mohs, R. C., andDavis, K. L. 1983. The cholinergic treatment strategy in aging and senile dementia. Psychopharm. Bull. 19:185–197.Google Scholar
  7. 7.
    Janowsky, D. S., El-Yousef, M. K., Davis, J. M., andSekerke, H. J. 1972. A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2:632–635.PubMedGoogle Scholar
  8. 8.
    Stahl, S. M., andBerger, P. A. 1982. Neuroleptic effects in Tourette syndrome predict dopamine excess and acetylcholine deficiency. Biol. Psychiat. 17:1047–1053.PubMedGoogle Scholar
  9. 9.
    Milstoc, M., Teodoru, C. V., Fieve, R. R., andKumbaraci, T. 1975. Cholinesterase activity and the manic-depressive patients. Dis. of the Nerv. System 36:197–199.Google Scholar
  10. 10.
    Chipperfield, B., Newman, P. M., andMoyes, I. C. A. 1981. Decreased erythrocyte cholinesterase activity in dementia. Lancet 1:199.PubMedGoogle Scholar
  11. 11.
    Perry, E. K., Perry, R. H., Blessed, G., andTomlinson, B. E. 1978. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropath. Appl. Neurobiol. 4:273–277.Google Scholar
  12. 12.
    Deutsch, S. I., Mohs, R. C., andDavis, K. L. 1982. A rationale for studying the transmissibility of Alzheimer's disease. Neurobiol. Aging 3:145–147.PubMedGoogle Scholar
  13. 13.
    Perry, R. H., Wilson, I. D., Bober, M. J., Atack, J., Blessed, G., Tomlinson, B. E., andPerry, E. K. 1982. Plasma and erythrocyte acetylycholinesterase in senile dementia of Alzheimer type. Lancet 2:174–175.PubMedGoogle Scholar
  14. 14.
    Smith, R. C., Ho, B. T., Hsu, L., Vroulis, G. A., Glaghorn, J., andSchoolar, J. 1982. Cholinesterase enzymes in the blood of patients with Alzheimer's disease. Life Sci. 30:543–546.PubMedGoogle Scholar
  15. 15.
    Deutsch, S. I., Mohs, R. C., Levy, M. I., Rothpearl, A. B., Stockton, D., Horvath, T., Coco, A., andDavis, K. L. 1983. Acetylcholinesterase activity in CSF in schizophrenia, depression, Alzheimer's disease and normals. Biol. Psychiatr. 18:1363–1373.Google Scholar
  16. 16.
    Mathew, R. J., Ho, B. T., Khan, M. M., Perales, C., Weinan, M. L., andClaghorn, J. L. 1982. True and pseudocholinesterases in depression. Am. J. Psychiat. 139:125–127.PubMedGoogle Scholar
  17. 17.
    Fieve, R. R., Milstoc, M., Kumbaraci, T., andDunner, D. L. 1976. The effect of lithium on red blood cell cholinesterase activity in patients with affective disorders. Dis. Nerv. System 37:240–243.Google Scholar
  18. 18.
    Domino, E. F., andKrause, R. R. 1972. Reexamination of red cell and plasma cholinesterase activity in drug-free chronic schizophrenic patients and normals. Biol. Psychiatr. 4:17–31.Google Scholar
  19. 19.
    Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III), 1980, American Psychiatric Association, Washington, D.C.Google Scholar
  20. 20.
    Lucas, A. R., Krause, R. R., andDomino, E. F. 1971. Biological studies in childhood schizophrenia: plasma and RBC cholinesterase activity. J. Autism Child. Schiz. 1:72–81.Google Scholar
  21. 21.
    Bender, L. 1947. Childhood schizophrenia: clinical study of one hundred schizophrenic children. Am. J. Orthopsychiat. 17:40–56.Google Scholar
  22. 22.
    Rabinovitch, R. D., Lucas, A. R., andIngram, W. 1965. Childhood schizophrenia: Evolution to adulthood. Paper presented at American Orthopsychiatric Association Annual Meeting, New York, March 1965.Google Scholar
  23. 23.
    Young, J. G., Kavanagh, M. E., Anderson, G. M., Shaywitz, B. A., andCohen, D. J. 1982. Clinical neurochemistry of autism and associated disorders. J. Autism Dev. Disorders 12:147–165.Google Scholar
  24. 24.
    Festoff, B. W., andFernandez, H. L. 1981. Plasma and red blood cell acetylcholinesterase in amyotrophic lateral sclerosis. Muscle & Nerve 4:41–47.Google Scholar
  25. 25.
    Deutsch, S. I., andDavis, K. L. 1983. Schizophrenia: A review of diagnostic and biological issues. I. Diagnosis and Prognosis. Hosp. Community Psychiat. 34:313–322.Google Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Stephen I. Deutsch
    • 1
    • 2
  • Magda Campbell
    • 1
    • 2
  1. 1.Department of PsychiatryNew York University School of MedicineNew York
  2. 2.Department of PsychiatryNew York University School of MedicineNew YorkUSA

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