Neurochemical Research

, Volume 9, Issue 7, pp 863–869 | Cite as

Status of cholinesterase activities in blood in neuropsychiatric disorders

  • Stephen I. Deutsch
  • Magda Campbell
An Overview

Abstract

The availability of easily accessible biochemical trait markers of central cholinergic activity would assist in the identification of homogeneous subgroups of neuropsychiatric patients within specific diagnostic categories. In addition to a refinement of nosology, these measures could also help to design specific treatment interventions. The activities of cholinesterase isoenzymes in blood have been reported to be abnormal in neuropsychiatric disorders with proven or hypothesized abnormalities of central cholinergic transmission. However, the relevance of these peripheral cholinesterase abnormalities to disordered central cholinergic transmission remains uncertain. Future studies examining specific cholinesterase isoenzymes in homogeneous diagnostic groups are needed to determine the potential utility of these measures as peripheral trait markers of central cholinergic activity.

Keywords

Future Study Specific Treatment Cholinesterase Potential Utility Diagnostic Category 

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Stephen I. Deutsch
    • 1
    • 2
  • Magda Campbell
    • 1
    • 2
  1. 1.Department of PsychiatryNew York University School of MedicineNew York
  2. 2.Department of PsychiatryNew York University School of MedicineNew YorkUSA

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