Neurochemical Research

, Volume 4, Issue 5, pp 627–631 | Cite as

Effect of met-enkephalin and (d-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain

  • M. Wollemann
  • A. Szebeni
  • S. Bajusz
  • L. Gráf
Original Articles


Among opiatelike peptides, stimulatory as well as inhibitory effects are encountered on adenylate cyclase activity. These actions are dependent not only on the investigated brain region but also on the applied peptide. Met-enkephalin stimulates adenylate cyclase activity in the rat brain stem (d-Met2, Pro5)-enkephalinamide and β-endorphin inhibited it, whereas all three peptides inhibited the activity of cortex. Naloxone antagonized the effects of the applied peptides in the presence of sodium chloride.


Sodium Peptide Chloride Sodium Chloride Brain Region 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • M. Wollemann
    • 1
    • 2
  • A. Szebeni
    • 1
    • 2
  • S. Bajusz
    • 1
    • 2
  • L. Gráf
    • 1
    • 2
  1. 1.Institute of BiochemistryBiological Center Hungarian Academy of SciencesSzegedHungary
  2. 2.Institute for Drug ResearchBudapestHungary

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