Neurochemical Research

, Volume 9, Issue 4, pp 577–585 | Cite as

Induced enzyme release from synaptosomes by halothane

  • S-C. Cheng
  • E. A. Brunner
  • I. A. Minieka
Original Articles


GABA-transaminase has been found to be released from rat brain synaptosomes by halothane in a dose-related manner. The releases of both GABA-transaminase and succinic semialdehyde dehydrogenase were increased with time. The release of other enzymes (creatine kinase, glutamate decarboxylase, aspartate transaminase, lactate dehydrogenase, and malate dehydrogenase) was less in magnitude and not related to the duration of incubation. Such observations suggested a specific event in the halothane-induced release of GABA-catabolizing enzymes. A suggestion linking mode of anesthetic action to a mitochondrial effect of volatile anesthetics was made.


Lactate Glutamate Creatine Creatine Kinase Halothane 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • S-C. Cheng
    • 1
  • E. A. Brunner
    • 1
  • I. A. Minieka
    • 1
  1. 1.Department of AnesthesiaNorthwestern University Medical SchoolChicago

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