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Neurochemical Research

, Volume 9, Issue 4, pp 497–505 | Cite as

Distribution and characterization of the glutamate receptors in the CNS of ataxic mutant mouse

  • Tomoko Yamaguchi
  • Keirei Hayashi
  • Hirohiko Murakami
  • Shoichi Maruyama
  • Masashi Yamaguchi
Original Articles

Abstract

In a search for neurochemical involvement in cerebellar ataxia, Rolling Mouse Nagoya (C3Hf/Nem-rol), which shows only hypoplasia of the cerebellum but no pathological configuration of the cerebellar structure, was used to study glutamate receptors in the CNS. Kainic acid binding sites were significantly decreased in the thalamus, hypothalamus, pons, and cerebellum, and in the frontal cortex of both the ataxic mutant mouse and the non-ataxic heterozygote. Only spinal cord and midbrain of the ataxic mutant mouse showed decreased distribution of kainate binding sites in the membrane fraction.

Among enzymes responsible for supplying glutamate to the receptor, GDH showed higher activity in the spinal cord of the ataxic mutanat mouse.

Keywords

Spinal Cord Glutamate Binding Site High Activity Frontal Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Tomoko Yamaguchi
    • 1
  • Keirei Hayashi
    • 1
  • Hirohiko Murakami
    • 2
  • Shoichi Maruyama
    • 2
  • Masashi Yamaguchi
    • 3
  1. 1.Department of BiochemistryTokyo Women's Medical CollegeTokyoJapan
  2. 2.Department of NeurologyTokyo Women's Medical CollegeTokyoJapan
  3. 3.Department of NeuropsychiatryShowa University School of MedicineTokyoJapan

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