Neurochemical Research

, Volume 3, Issue 1, pp 37–48 | Cite as

Myelin basic protein-stimulated rosette-forming T cells in multiple sclerosis

  • George A. Hashim
  • Duk H. Lee
  • James C. Pierce
  • Carl W. Braun
  • Hugh F. Fitzpatrick
Original Articles

Abstract

A subpopulation of T lymphocytes sensitized to human myelin basic protein in peripheral blood of patients with multiple sclerosis, central nervous system (CNS) tumors, and cerebrovascular accidents was demonstrated by the antigen-stimulated, rosette-forming T cell assay. A significant increase in the percent of active rosette-forming T cells was detected after in vitro exposure of peripheral blood lymphocytes to human myelin basic protein but not to histones. In contrast, peripheral blood lymphocytes from healthy controls and from patients with benign and malignant breast diseases were unresponsive to stimulation by either antigen. These results demonstrate a functionally active T-lymphocyte subpopulation sensitized to myelin basic protein in patients with multiple sclerosis and in patients with certain other CNS diseases.

Keywords

Nervous System Central Nervous System Multiple Sclerosis Blood Lymphocyte Peripheral Blood Lymphocyte 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • George A. Hashim
    • 1
  • Duk H. Lee
    • 1
  • James C. Pierce
    • 1
  • Carl W. Braun
    • 1
  • Hugh F. Fitzpatrick
    • 1
  1. 1.St. Luke's Hospital Center and Columbia UniversityNew York

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