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Pathologisch-anatomische Befunde bei experimentellem Magnesium-Mangel des Hundes

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Zusammenfassung

Die pathologisch anatomischen Befunde von 16 Mg-arm ernährten Hunden im Vergleich zu 8 Kontrolltieren werden geschildert: ausgedehnte Gewebsverkalkungen erstrecken sich in erster Linie auf das cardiovasculäre System, die Alveolarsepten der Lungen, die Bronchial- sowie die Kehlkopf- und Trachealschleimhaut und vereinzelt auf die Mucosa des Magens und die Muskulatur des Skelets und Zwerchfells. Die Gewebe schienen vor der Ablagerung der Calciumsalze keine Veränderung aufzuweisen. Als Ursache für die Gewebsverkalkungen wird die relative Hypercalcämie bei niedrigem Serum-Mg-Spiegel diskutiert und auf Beziehungen zur Kalkmetastase bzw. Kalkgicht hingewiesen.

Summary

The anatomical and pathological findings of 16 dogs fed with a magnesium-deficient diet are compared with those of 8 normally fed animals. There was an extensive calcification of the tissues especially of the cardiovascular system, of the alveolar septa of the lungs, the mucous membranes of the bronchi as well as of the larynx and the trachea, and to a lesser degree in the gastric mucosa and the muscles of the skeleton and diaphragm. Prior to the deposition of calcium salts the tissues seemed unchanged. A relative hypercalcemia associatid with a low serum-magnesium-level is discussed as the possible cause of the tissue calcifications. The relation to metastatic calcification (Kalkmetastase) or to the so-called calcium-gout (Kalkgicht) is pointed out.

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Authors and Affiliations

  1. Pathologischen Institut der Humboldt-Universität Berlin, Deutschland

    I. Unglaub, I. Syllm-Rapoport & I. Strassburger

  2. Physiologisch-chemischen Institut der Humboldt-Universität Berlin, Deutschland

    I. Unglaub, I. Syllm-Rapoport & I. Strassburger

  3. Universitäts-Kinderklinik der Charité, Deutschland

    I. Unglaub, I. Syllm-Rapoport & I. Strassburger

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  1. I. Unglaub
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  2. I. Syllm-Rapoport
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  3. I. Strassburger
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Unglaub, I., Syllm-Rapoport, I. & Strassburger, I. Pathologisch-anatomische Befunde bei experimentellem Magnesium-Mangel des Hundes. Virchows Arch. path Anat. 332, 122–131 (1959). https://doi.org/10.1007/BF00964216

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  • DOI: https://doi.org/10.1007/BF00964216

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