Skip to main content
Log in

Proteins of myelin and their metabolism

  • Overview
  • Published:
Neurochemical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Raine, C. S. 1976. Neurocellular Anatomy. Pages 5–33,In Siegel, G. J., Albers, R., Katzman, R., and Agranoff, B. W. (eds.), Basic Neurochemistry, second edition, Little, Brown and Co., Boston.

    Google Scholar 

  2. Raine, C. S. 1977. Morphological aspects of myelin and myelination. Pages 1–49,In Morell, P. (ed.), Myelin, Plenum Publishing Corp., New York.

    Google Scholar 

  3. Laatsch, R. H., Kies, M. W., Gordon, S., andAlvord, E. C., Jr. 1962. The encephalomyelitic activity of myelin isolated by ultracentrifugation. J. Exp. Med. 115:777–788.

    Google Scholar 

  4. DeRobertis, E., Pellegrino de I., Rodriguez, de L. A., andSalganicoff, L. 1962. Cholinergic and non-cholinergic nerve endings in rat brain. I. Isolation and subcellular distribution of acetylcholine and acetylcholinesterase. J. Neurochem. 9:23–35.

    Google Scholar 

  5. Nussbaum, J., Bieth, L., andMandel, P. 1963. Phosphatides in myelin sheaths and repartition of sphingomyelin in the brain (rat). Nature. 198:586.

    Google Scholar 

  6. Norton, W. T. 1976. Formation, Structure, and Biochemistry of Myelin. Pages 74–99,In Siegel, G. J., Albers, R. W., Katzman, R., and Agranoff, B. W. (eds.), Basic Neurochemistry, second edition, Little, Brown and Co., Boston.

    Google Scholar 

  7. Norton, W. T. 1977. Isolation and characterization of myelin. Pages 161–199,In Morell, P. (ed.) Myelin, Plenum Press, New York.

    Google Scholar 

  8. Norton, W. T., andPoduslo, S. E. 1973. Myelination in rat brain: Method of myelin isolation. J. Neurochem. 21:749–757.

    Google Scholar 

  9. Kies, M. W., Murphy, J. B., andAlvord, E. C. 1961. Studies of the encephalitogenic factor in guinea pig central nervous system. Pages 197–204,In Folch-Pi, J. (ed.), Chemical Pathology of the Nervous System, Pergamon Press, Oxford.

    Google Scholar 

  10. Einstein, E. R., Robertson, D. M., DiCaprio, J. M., andMoore, W. 1962. The isolation from bovine spinal cord of a homogeneous protein with encephalitogenic activity. J. Neurochem. 9:353–361.

    Google Scholar 

  11. Folch, J., andLees, M. 1951. Proteolipides, a new type of tissue lipoproteins, their isolation from brain. J. Biol. Chem. 191:807–817.

    Google Scholar 

  12. Wolfgram, F., andKotorii, K. 1968. The composition of the myelin proteins of the central nervous system. J. Neurochem. 15:1281–1290.

    Google Scholar 

  13. Wolfgram, F., andKotorii, K. 1968. The composition of the myelin proteins of the peripheral nervous system. J. Neurochem. 15:1291–1295.

    Google Scholar 

  14. Einstein, E. R., Dalal, K. B., andCsejtey, J. 1970. Biochemical maturation of the central nervous system. II. Protein and proteolytic enzyme changes. Brain Res. 18:35–49.

    Google Scholar 

  15. Eng, L. F., Bond, P., andGerstl, B. 1971. Isolation of myelin proteins from disc acrylamide gels electrophoresed in phenol-formic acid-water. Neurobiol. 1:58–63.

    Google Scholar 

  16. Maizel, J. V., Jr. 1971. Polyacrylamide gel electrophoresis of viral proteins. Meth. Virol. 5:179–246.

    Google Scholar 

  17. Agrawal, H. C., Burton, R. M., Fishman, M. A., Mitchell, R. F., andPrensky, A. L. 1972. Partial characterization of a new myelin protein component. J. Neurochem. 19:2083–2089.

    Google Scholar 

  18. Waehneldt, T. V., andMandel, P. 1970. Proteins of rat brain myelin. Extraction with sodium dodecylsulphate and electrophoresis on analytical and preparative scale. FEBS Letters, 9:209–212.

    Google Scholar 

  19. Greenfield, S., Norton, W. T., andMorell, P. 1971. Quaking mouse: Isolation and characterization of myelin protein. J. Neurochem. 18:2119–2128.

    Google Scholar 

  20. Morell P., Greenfield, S., Costantino-Ceccarini, E., andWisniewski, H. 1972. Changes in the protein composition of mouse brain myelin during development. J. Neurochem. 19:2545–2554.

    Google Scholar 

  21. Eng, L. F., Chao, F. C., Gerstl, B., Pratt, D., andTravaststjerna, M. G. 1968. The maturation of human white matter myelin. Fractionation of the myelin membrane proteins. Biochemistry 7:4455–4465.

    Google Scholar 

  22. Gonzalez-Sastre, F. 1970. The protein composition of isolated myelin. J. Neurochem. 17:1049–1056.

    Google Scholar 

  23. Folch-Pi, J. 1973. Proteolipids. Pages 45–66,In Schneider, D. J. (ed.), Proteins of the Nervous System, Raven Press, New York.

    Google Scholar 

  24. Lees, M. B., andChan, D. S. 1975. Proteolytic digestion of bovine brain white matter proteolipid. J. Neurochem. 25:595–600.

    Google Scholar 

  25. Nussbaum, J. L., Rouayrenc, J. F., andMandel, P. 1974. Isolation and terminal sequence determination of the major rat brain myelin proteolipid P7 apoprotein. Biochem. Biophys. Res. Commun. 57:1240–1247.

    Google Scholar 

  26. Chan, D. S., andLees, M. D. 1977. Acid soluble tryptic peptides from bovine white matter proteolipids. Trans. Am. Soc. Neurochem. 8:157 abstract.

    Google Scholar 

  27. Chan, D. S., andLees, M. B. 1974. Gel electrophoresis studies of bovine brain white matter proteolipid and myelin proteins. Biochemistry 13:2704.

    Google Scholar 

  28. Gagnon, J., Finch, P. R., Wood D. D., andMoscarello, M. A. 1971. Isolation of a highly purified myelin protein. Biochem. 10:4756–4763.

    Google Scholar 

  29. Folch-Pi, J., andStoffyn, P. J. 1972. Proteolipids from membrane systems. Ann. N. Y. Acad. Sci. 195: 86–107.

    Google Scholar 

  30. Nussbaum, J. L., andMandel, P. 1973. Brain proteolipids in neurological mutant mice. Brain Res. 61:295–310.

    Google Scholar 

  31. Lerner, P., Campagnoni, A. T., andSampugna, J. 1974. Proteolipids in the developing brains of normal and mutant mice. J. Neurochem. 22:163–170.

    Google Scholar 

  32. Agrawal, H. C., Hartman, B. K., Shearer, W. T., Kalmbach, S., andMargolis, F. L. 1977. Purification and immunohistochemical localization of rat brain myelin proteolipid protein. J. Neurochem. 28: 495–508.

    Google Scholar 

  33. Nicot, C., Le, N. T., Lepretre, M., andAlfsen, A. 1973. Study of Folch-Pi apoprotein. I. Isolation of two components, aggregation during delipidation. Biochim. Biophys. Acta. 322:109–123.

    Google Scholar 

  34. Morell, P., Wiggins, R. C., andGray, M. J. 1975. Polyacrylamide gel electrophoresis of myelin proteins: A caution. Anal. Biochem. 68:148–154.

    Google Scholar 

  35. Cammer, W., andNorton, W. T. 1976. Disc gel electrophoresis of myelin proteins: new observations on development of the intermediate proteins (DM-20). Brain Res. 109:643–648.

    Google Scholar 

  36. Morell, P., Lipkind, R., andGreenfield, S. 1973. Protein composition of myelin from brain and spinal cord of several species. Brain Res. 58:510–514.

    Google Scholar 

  37. Quarles, R. H., Everly, J. H., andBrady, R. O. 1972. Demonstration of a glycoprotein which is associated with a purified myelin fraction from rat brain. Biochem. Biophys. Res. Commun. 47:491–497.

    Google Scholar 

  38. Fujimoto, K., Burton, R. M., andAgrawal, N. C. 1975. Incorporation of3H-5,6 fucose into myelin proteins. Trans. Am. Soc. Neurochem. 6:212 abstract.

    Google Scholar 

  39. Poduslo, J. F., Everly, J. L., andQuarles, R. H. 1977. A low molecular weight glycoprotein associated with isolated myelin: Distinction from myelin proteolipid protein. J. Neurochem. 28:944–986.

    Google Scholar 

  40. Magno-Sumbilla, C., andCampagnoni, A. T. 1977. Factors affecting the electrophoretic analysis of myelin-proteins: Application to changes occurring during brain development. Brain Res. 126:131–148.

    Google Scholar 

  41. Braun, P. E., andBrostoff, S. W. 1977. Proteins of myelin. Pages 201–231,In Morell, P. (ed.) Myelin, Plenum Press, New York.

    Google Scholar 

  42. Moscarello, M. A., Gagnon, J., Wood, D. D., Anthony, J., andEpand, R. 1973. Conformational flexibility of a myelin protein. Biochem. 12:3402–3406.

    Google Scholar 

  43. Eylar, E. H. 1970. Amino acid sequence of the basic protein of the myelin membrane. Proc. Natl. Acad. Sci. 67:1425–1431.

    Google Scholar 

  44. Carnegie, P. R. 1971. Amino acid sequence of the encephalitogenic basic protein from human myelin. Biochem. J. 123:57–67.

    Google Scholar 

  45. Brostoff, S. W. 1977. Immunological responses to myelin and myelin components. Pages 415–446,In Morell, P. (ed.), Myelin, Plenum Press, New York.

    Google Scholar 

  46. Martenson, R. E., Deibler, G. E., andKies, M. W. 1970. Rat myelin basic proteins: Relationship between size difference and microheterogeneity. J. Neurochem. 17:1329–1330.

    Google Scholar 

  47. Dunkley, P. R., andCarnegie, P. R. 1974. Amino acid sequence of the smaller basic protein from rat brain myelin. Biochem. J. 141:243–255

    Google Scholar 

  48. Eylar, E. H., andThompson, M. 1969. Allergic encephalomyelitis: The physicochemical properties of the basic protein encephalitogen from bovine spinal cord. Arch. Biochem. Biophys. 129:468–479.

    Google Scholar 

  49. Palmer, F. B. andDawson, R. M. C. 1969. The isolation and properties of experimental allergic encephalitogenic protein. Biochem. J. 111:629–636.

    Google Scholar 

  50. Anthony, J. S., andMoscarello, M. A. 1971. A conformation change induced in the basic encephalitogen by lipids. Biochim. Biophys. Acta 243:429–433.

    Google Scholar 

  51. Epand, R. M., Moscarello, M. A., Zierenberg, B., andVail, W. J. 1974. The folded conformation of the encephalitogenic protein of the human brain. Biochemistry 13:1264–1267.

    Google Scholar 

  52. Marks, N. Grynbaum, A., andLajtha, A. 1976. The breakdown of myelin-bound proteins by intra-and extracellular proteases. Neurochem. Res. 1:93–111.

    Google Scholar 

  53. Smith, M. E. 1977. The role of proteolytic enzymes in demyelination in experimental allergic encephalomyelitis. Neurochem. Res. 2:233–246.

    Google Scholar 

  54. Brostoff, S., andEylar, E. H.: 1971. Localization of methylated arginine in the A1 protein from myelin. Proc. Natl. Acad. Sci. 68:765–769.

    Google Scholar 

  55. Baldwin, G. S., andCarnegie, P. R. 1971. Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin, Sci. 171:579–581.

    Google Scholar 

  56. Miyake, M. 1975. Methylases of myelin basic protein and histone in rat brain. J. Neurochem. 24:909–915.

    Google Scholar 

  57. Deibler, G. E., andMartenson, R. E. 1973. Determination of methylated basic amono acids with the amino acid analyzer: Application to total acid hydrolyzates of myelin basic proteins. J. Biol. Chem. 248:2387–2391.

    Google Scholar 

  58. Carnegie, P. R., Kemp, B. E., Dunkley, P. R., andMurray, A. W. 1973. Phosphorylation of myelin basic protein by an adenosine 3′-5′-cyclic monophosphate-dependent protein kinase. Biochem. J. 135:569–572.

    Google Scholar 

  59. Steck, A. J., andAppel, S. H. 1974. Phosphorylation of myelin basic protein. J. Biol. Chem. 249:5416–5420.

    Google Scholar 

  60. Miyamoto, E., andKakiuchi, S. 1974In vitro andin vivo phosphorylation of myelin basic protein by exogenous and endogenous adenosine 3′, 5′-monophosphate-dependent protein kinases in brain. J. Biol. Chem. 249:2769–2777.

    Google Scholar 

  61. Miyamoto, E. 1976. Phosphorylation of endogenous protein in myelin of rat brain. J. Neurochem. 26:573–577.

    Google Scholar 

  62. Deibler, G. E., Martenson, R. E., Kramer, A. J., andKies, M. W. 1975. The contribution of phosphorylation and loss of COOH-terminal arginine to the microheterogeneity of myelin basic protein. J. Biol. Chem. 250:7931–7938.

    Google Scholar 

  63. Chou, F. C-H., Chou, J., Shapira, R., andKibler, R. F. 1977. Modifications of myelin basic protein which occur during its isolation. J. Neurochem. 28:1051–1059.

    Google Scholar 

  64. Allison, J. H., Agrawal, H. C., andMoore, B. W. 1974. Effect N,N,N′,N′-tetramethylethylenediamine on the migration of proteins in SDS polyacrylamide gels. Anal. Biochem. 58:592–601.

    Google Scholar 

  65. Barbarese, E., Braun, P. E., andCarson, J. H. 1977. Identification of pre-large and pre-small basic protein in mouse myelin and their structural relationship to large and small basic protein. Proc. Natl. Acad. Sci. 74:3360–3364.

    Google Scholar 

  66. Wolfgram, F. 1966. A new proteolipid fraction of the nervous system. I. Isolation and amino acid analyses. J. Neurochem. 13:461–470.

    Google Scholar 

  67. Wiggins, R. C., Joffe, S., Davidson, D., andDel Valle, U. 1974. Characterization of Wolfgram proteolipid protein of bovine white matter and fractionation of molecular weight heterogeneity. J. Neurochem. 2:171–175.

    Google Scholar 

  68. Nussbaum, J. L., Delaunoy, J. P., andMandel, P. 1977. Some immunochemical characteristics of W1 and W2 Wolfgram proteins isolated from rat brain myelin. J. Neurochem. 26:183–191.

    Google Scholar 

  69. Roussel, G., Delaunoy, J. P., Nussbaum, J. L., andMandel, P. 1977. Immunohistochemical localization of Wolfgram proteins in nervous tissue of rats. Neurosci. 2:307–313.

    Google Scholar 

  70. Banik, N. L., andDavison, A. N. 1969. Enzyme activity and composition of myelin and subcellular fraction in the developing rat brain. Biochem. J 115:1051–1062.

    Google Scholar 

  71. Marks, N. 1972. Myelin enzymes and protein metabolism. Adv. Exp. Med. Biol. 32:263.

    Google Scholar 

  72. Olafson, R. W., Drummond, G. I. andLee, J. F. 1969. Studies on 2′, 3′-cyclic nucleotide-3′-phosphohydrolase from brain. Can. J. Biochem. 47:961–966.

    Google Scholar 

  73. Braun, P. E., andBarchi, R. L. 1972. 2′, 3′-cyclic nucleotide 3′-phosphodiesterase in the nervous system. Electrophoretic properties and developmental studies. Brain Res. 40:437–444.

    Google Scholar 

  74. Fishman, M. A., Agrawal, H. C., Alexander, A., andGolterman, J. 1975. Biochemical maturation of human central nervous system myelin. J. Neurochem. 24:689–694.

    Google Scholar 

  75. Poduslo, S. E., andNorton, W. T. 1972. Isolation and some chemical properties of oligodendroglia from calf brain. J. Neurochem. 19:727–736.

    Google Scholar 

  76. Guha, A., andMoore, S. 1975. Solubilization of 2′, 3′-cyclic nucleotide 3′-phosphohydrolase from bovine brain without detergents. Brain Res. 89:279–286.

    Google Scholar 

  77. Eto, Y., andSuzuki, K. 1973. Cholesterol ester metabolism in rat brain: A cholesterol ester hydrolase specifically localized in the myelin sheath. J. Biol. Chem. 248:1986–1991.

    Google Scholar 

  78. Igarashi, M., andSuzuki, K. 1976. Effect of exogenous lipids on activities of the rat brain cholesterol ester hydrolase localized in the myelin sheath. J. Neurochem. 27:859–866.

    Google Scholar 

  79. Neskovic, N. M., Sarlieve, L. L., andMandel, P. 1973. Subcellular and submicrosomal distribution of glycolipid-synthesizing transferases in jimpy and quaking mice. J. Neurochem. 20:1419–1425.

    Google Scholar 

  80. Costantino-Ceccarini, E., andSuzuki, K. 1975. UDP-Galactose ceramide galactosyl transferase in rat myelin. Trans. Am. Soc. Neurochem. 6:270 abstract.

    Google Scholar 

  81. Miyamoto, E., andKakiuchi, S. 1975. Phosphoprotein phosphatases for myelin basic protein in myelin and cytosol fractions of rat brain. Biochim. Biophys. Acta 384:458–465.

    Google Scholar 

  82. McNamara, J. O., andAppel, S. H. 1977. Myelin basic protein phosphatase activity in rat brain. J. Neurochem. 29:27–35.

    Google Scholar 

  83. Cammer, W., Fredman, T., Rose, A. L., andNorton, W. T. 1976. Brain carbonic anhydrase: activity in isolated myelin and the effect of hexachlorophene. J. Neurochem. 27:165–171.

    Google Scholar 

  84. Yandrasitz, J. R., Ernst, S. A., andSalganicoff, L. 1976. The subcellular distribution of carbonic anhydrase in homogenates of perfused rat brain. J. Neurochem. 27:707–715.

    Google Scholar 

  85. Sapirstein, V. S., andLees, M. B. 1977. Purification of myelin carbonic anhydrase. Trans. Am. Soc. Neurochem. 8:245.

    Google Scholar 

  86. Quarles, R. H., Everly, J. L., andBrady, R. O. 1973. Evidence for the close association of a glycoprotein with myelin in rat brain. J. Neurochem. 21:1177–1191.

    Google Scholar 

  87. Matthieu, J. M., Brady, R. O., andQuarles, R. H. 1975. Change in a myelinassociated glycoprotein in rat brain during development: Metabolic aspects. Brain Res. 86:55–65.

    Google Scholar 

  88. Matthieu, J. M., Quarles, R. H., Poduslo, J. F., andBrady, R. O. 1975. (35S)sulfate incorporation into myelin glycoproteins I. Central nervous system. Biochim. Biophys. Acta. 392:159–166.

    Google Scholar 

  89. Poduslo, J. F., andBraun, P. E. 1975. Topographical arrangement of membrane proteins in the intact myelin sheath. J. Biol. Chem. 250:1099–1105.

    Google Scholar 

  90. Golds, E. E., andBraun, P. E. 1976. Organization of membrane proteins in the intact myelin sheath. J. Biol. Chem. 251:4729–4735.

    Google Scholar 

  91. Wood, D. D., Epand, R. M., andMoscarello, M. A. 1977. Localization of the basic protein and lipophilin in the myelin membrane with a non-penetrating reagent. Biochim. Biophys. Acta 467:120–219.

    Google Scholar 

  92. Adams, C. W. M., Bayliss, O. B., Hallpike, J. F., andTurner, D. R. 1971. Histochemistry of myelin XII. Anionic staining of myelin basic proteins for histology, electrophoresis and electron microscopy. J. Neurochem. 18:389–394.

    Google Scholar 

  93. Herndon, R. M., Rauch, H. C., andEinstein, E. R. 1973. Immunoelectron microscopic localization of the encephalitogenic basic protein in myelin. Immunol. Commun. 2:163–172.

    Google Scholar 

  94. Kornguth, S. E., andAnderson, J. W. 1965. Localization of a basic protein in the myelin of various species with the aid of fluorescence and electron microscopy. J. Cell Biol. 26:157–166.

    Google Scholar 

  95. Guarnieri, M., Himmelstein, J., andMcKhann, G. M. 1974. Isolated myelin quantitatively adsorbs antibody to basic protein. Brain Res. 72:172–176.

    Google Scholar 

  96. Poduslo, J. F., Quarles, R. H., andBrady, R. O. 1976. External labeling of galactose in surface membrane glycoproteins of the intact myelin sheath. J. Biol. Chem. 251:153–158.

    Google Scholar 

  97. Matus, A., DePetris, S., andRaff, M. D. 1973. Mobility of concanavalin-A receptors in myelin and synaptic membranes. Nature (London) New Biol. 244:278–280.

    Google Scholar 

  98. Braun, P. 1977. Molecular architecture of myelin. Pages 91–115, Morell, P. (ed.), Myelin, Plenum Press, New York.

    Google Scholar 

  99. Adams, D. H., andOsborne, J. 1973. A developmental study of the relationship between the protein components of rat CNS myelin. Neurobiol. 3:91–112.

    Google Scholar 

  100. Zgorzalewicz, B., Neuhoff, V., andWaehneldt, T. V. 1974. Rat myelin proteins. Compositional changes in various regions of the nervous system during ontogenetic development. Neurobiol. 4:265–276.

    Google Scholar 

  101. Jones, D. H., andMatus, A. I. 1975. Changes in protein content of developing brain synaptic membranes, mitochondria and myelin. Neurosci. Letters 1:153–158.

    Google Scholar 

  102. Banik, N. L., andSmith, M. E. 1977. Protein determinants of myelination in different regions of developing rat central nervous system. Biochem. J. 162:247–255.

    Google Scholar 

  103. Banik, N. D., Davison, A. N., Ramsey, R. B., andScott, T. 1974. Protein composition in developing human brain myelin. Develop. Psychobiol. 7:539–549.

    Google Scholar 

  104. Kelly, P. T., andLuttges, M. W. 1976. Mouse brain protein composition during postnatal development: an electrophoretic analysis. J. Neurochem. 27:1163–1172.

    Google Scholar 

  105. Foulkes, J. A., andPatterson, D. S. P. 1974. Myelin cerebrosides and proteins in the spinal cord of the pig during pre-and post-natal development. Brain Res. 82:139–149.

    Google Scholar 

  106. Tennekoon, G. I., Cohen, S. R., Price, D. L., andMcKhann, G. M. 1977. Myelinogenesis in optic nerve. J. Cell Biol. 72:604–616.

    Google Scholar 

  107. Detering, N. K., andWells, M. A. 1976. Detection of myelin in the optic nerve of young rats by sedimentation equilibrium in a CsCl gradient. J. Neurochem. 26:247–252.

    Google Scholar 

  108. Detering, N. K., andWells, M. A. 1976. The non-synchronous synthesis of myelin components during early stages of myelination in the rat optic nerve. J. Neurochem. 26:253–257.

    Google Scholar 

  109. Quarles, R. H., Everly, J. L., andBrady, R. O. 1973. Myelin-associated glycoprotein: a developmental change. Brain Res. 58:506–509.

    Google Scholar 

  110. Brady, R. O., andQuarles, R. H. 1973. The enzymology of myelination. Mol. Cell. Biochem. 2:23–29.

    Google Scholar 

  111. Lees, M. B., andPaxman, S. A. 1974. Myelin proteins from different regions of the central nervous system. J. Neurochem. 23:825–831.

    Google Scholar 

  112. Smith, M. E., andSedgewick, L. M. 1975. Studies of the mechanism of demyelination. Regional differences in myelin stabilityin vitro. J. Neurochem. 24:763–770.

    Google Scholar 

  113. Autilio, L. A., Norton, W. T., andTerry, R. D. 1964. The preparation and some properties of purified myelin from the central nervous system. J. Neurochem. 11:17–27.

    Google Scholar 

  114. Eng, L. F., andNoble, E. P. 1968. The maturation of rat brain myelin. Lipids 3:157–161.

    Google Scholar 

  115. Adams, D. H., andFox, M. E. 1969. The homogeneity and protein composition of rat brain myelin. Brai Res. 14:647–661.

    Google Scholar 

  116. Cuzner, M. L., andDavison, A. N. 1968. The lipid composition of rat brain myelin and subcellular fractions during development. Biochem. J. 106:29–34.

    Google Scholar 

  117. McMillan, P. N., Williams, N. I., Kaufman, B., andDay, E. D. 1972. The isolation and biochemical characterization of three subfractions of myelin from central nervous tissue of the adult rat. J. Neurochem. 19:1839–1848.

    Google Scholar 

  118. Matthieu, J. M., Quarles, R. H., Poduslo, J. F., Brady, R. O., andWebster, H. deF. 1973. Variation of proteins, enzyme markers and gangliosides in myelin subfractions. Biochim. Biophys. Acta 329:305–317.

    Google Scholar 

  119. Benjamins, J. A., Miller, K., andMcKhann, G. M. 1973. Myelin subfractions in developing rat brain: characterization and sulphatide metabolism. J. Neurochem. 20:1589–1603.

    Google Scholar 

  120. Agrawal, H. C., Trotter, J. L., Burton, R. M., andMitchell, R. F. 1974. Evidence for a precursor role of a myelin subfraction. Biochem. J. 140:99–109.

    Google Scholar 

  121. Fujimoto, K., Roots, B. I., Burton, R. M., andAgrawal, H. C. 1976. Morphological and biochemical characterization of light and heavy myelin isolated from developing rat brain. Biochim. Biophys. Acta 426:659–668.

    Google Scholar 

  122. Sheads, L. E., Eby, M. J., andSampugna, J. 1976. Myelin subfractions isolated from mouse brain. Studies of normal mice during development, quaking mutants, and three brain regions. J. Neurobiol. 8:67–89.

    Google Scholar 

  123. Hofteig, J. H., andDruse, M. J. 1976. Metabolism of three subfractions of myelin in developing rats. Life Sci. 18:543–552.

    Google Scholar 

  124. Zimmerman, A. W., Quarles, R. H., Webster, H. deF., Matthieu, J. M., andBrady, R. O. 1975. Characterization and protein analysis of myelin subfractions in rat brain: Developmental and regional comparisons. J. Neurochem. 25:749–757.

    Google Scholar 

  125. Waehneldt, T. V., 1975. Ontogenetic study of a myelin-derived fraction with 2′,3′-cyclic nucleotide 3′-phosphohydrolase activity higher than that of myelin. Biochem. J. 151:435–437.

    Google Scholar 

  126. Benjamins, J. A., Gray, M., andMorell, P. 1976. Metabolic relationships between myelin subfractions: Entry of proteins. J. Neurochem. 27:571–575.

    Google Scholar 

  127. Agrawal, H. C., Banik, N. L., Bone, A. H., Davison, A. N., Mitchell, R. F., andSpohn, M. 1970. The identity of a myelin-like fraction isolated from developing brain. Biochem. J. 120:635–642.

    Google Scholar 

  128. Agrawal, H. C., Trotter, J. L., Mitchell, R. F., andBurton, R. M. 1973. Criteria for identifying a myelin-like fraction from developing brain. Biochem. J. 136:1117–1119.

    Google Scholar 

  129. Waehneldt, T. V., andMatthieu, J. M. 1977. Characterization of a myelin-related fraction (SN 4). Trans. Am. Soc. Neurochem. 8:242 abstract.

    Google Scholar 

  130. Fewster, M. E., Einstein, E. R., Csejjtey, J., andBlackstone, S. C. 1974. Proteins in the bovine oligodendroglia cells at various stages of brain development. Neurobiol. 4:388–401.

    Google Scholar 

  131. McDermott, J. R., andWisniewski, H. M. 1977. Studies on the myelin protein changes and antigenic properties of rabbit sciatic nerves undergoing Wallerian degeneration. J. Neurol. Sci. 33:81–94.

    Google Scholar 

  132. Raine, C. S., Wisneiwski, H. M., Iqbal, K., Grundke-Iqbal, I., andNorton, W. T. 1977. Studies on the encephalitogenic effects of purified preparations of human and bovine oligodendrocytes. Brain Res. 120:269–286.

    Google Scholar 

  133. Poduslo, S. E. 1975. The isolation and characterization of a plasma membrane and a myelin fraction derived from oligodendroglia of calf brain. J. Neurochem. 24:647–654.

    Google Scholar 

  134. Poduslo, S. E., Miller, K., Piasecki, B., andMcKhann, G. M. 1977. Metabolic properties of maintained oligodendroglia. Trans. Am. Soc. Neurochem. 8:141 abstract.

    Google Scholar 

  135. Banik, N. L., andSmith, M. E. 1976. In vitro protein synthesis by oligodendroglial cells. Neurosci. Letters 2:235–238.

    Google Scholar 

  136. Poduslo, S. E., McFarland, H. F., Miller, K., Kroen, C., andMcKhann, G. M. 1976. Maintenance of bulk isolated oligodendroglia. Trans. Am. Soc. Neurochem. 7:90 abstract.

    Google Scholar 

  137. Abramsky, O., Pleasure, D., Silberberg, D., Quinn, B., andParris, J. 1977. Biochemical studies of oligodendrocytes from calf brain. Trans. Am. Soc. Neurochem. 8:143 abstract.

    Google Scholar 

  138. Brostoff, S. W., Greenfield, S., andHogan, E. L. 1977. The differentiation of synthesis from incorporation of basic protein in quaking mutant mouse myelin. Brain Res. 120:517–520.

    Google Scholar 

  139. Greenfield, S., Brostoff, S., andHogan, E. 1977. Evidence for defective incorporation of proteins in myelin of the quaking mutant mouse. Brain Res. 120:1507–1515.

    Google Scholar 

  140. Benjamins, J. A., Herschkowitz, N., Robinson, J., andMcKhann, G. M. 1971. The effects of inhibitors of protein synthesis on incorporation of lipids into myelin. J. Neurochem. 18:729–728.

    Google Scholar 

  141. Smith, M. E., andHasinoff, C. M. 1971. Biosynthesis of myelin proteins in vitro. J. Neurochem. 18:739–747.

    Google Scholar 

  142. Benjamins, J. A., Morell, P. 1978. Assembly of myelin.In Roberts, S. (ed.), Mechanisms, Regulation and Special Functions of Protein Synthesis in the Brain, Elsevier Press, Amsterdam.

    Google Scholar 

  143. Johnson, J. D., King, N. L., andBinkley, F. 1976. Atypical incorporation of single amino acids into myelin proteins. J. Neurochem. 26:361–367.

    Google Scholar 

  144. Palade, G. 1975. Intracellular aspects of the process of protein synthesis. Science 189:347–358.

    Google Scholar 

  145. Rothman, J. E., andLenard, J. 1977. Membrane asymmetry. Sci. 195:743–753.

    Google Scholar 

  146. Klee, C. B., andSokoloff, L. 1965. Amino acid incorporation into proteolipid of myelin in vitro. Proc. Natl. Acad. Sci. 53:1014–1021.

    Google Scholar 

  147. Pleasure, D. E., Feldman, B., andProckop, D. J. 1973. Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nerve in vitro. J. Neurochem. 20:81–90.

    Google Scholar 

  148. Giorgi, P. P., Karlsson, J. O., Sjostrand, J., andField, E. J. 1973. Axonal flow and myelin protein in the optic pathway. Nature (London) New Biol. 244:121–124.

    Google Scholar 

  149. Autilio-Gambetti, L., Gambetti, P., andShafer, B. 1975. Glial and neuronal contribution to proteins and glycoproteins recovered in myelin fractions. Brain Res. 84:336–346.

    Google Scholar 

  150. Chiu, F.-C., andSmith, M. E. 1977. Studies on polysomes from rat spinal cord. Trans. Am. Soc. Neurochem. 8:132 abstract.

    Google Scholar 

  151. Smith, M. E. 1973. A regional survey of myelin development: Some compositional and metabolic aspects. J. Lipid Res. 14:541–551.

    Google Scholar 

  152. Smith, M. E., andBenjamins, J. A. 1977. Model systems for metabolic perturbations of myelin. Pages 447–488,In Morell, P. (ed.) Myelin, Plenum Press, New York.

    Google Scholar 

  153. Wood, P. M., andBunge, R. P. 1975. Evidence that sensory axons are mitogenic for Schwann cells. Nature 256:662–664.

    Google Scholar 

  154. Weinberg, H. J., andSpencer, P. S. 1976. Studies on the control of myelinogenesis. II. Evidence for neuronal regulation of myelin production. Brain Res. 113:363–378.

    Google Scholar 

  155. McMorris, F. A. 1977. Norepinephrine induction of glial-specific enzyme in vitro. Trans. Am. Soc. Neurochem. 8:143 abstract.

    Google Scholar 

  156. Aguayo, A. J., Epps, J., Charron, L., andBray, G. M. 1976. Multipotentiality of Schwann cells in cross-anastomosed and grafted myelinated and unmyelinated nerves: quantitative microscopy and radioautography. Brain Res. 104:1–20.

    Google Scholar 

  157. D'Monte, B., Mela, P., andMarks, N. 1971. Metabolic instability of myelin protein and proteolipid fractions. Eur. J. Biochem. 23:355–365.

    Google Scholar 

  158. Benjamins, J. A., Jones, M., andMorell, P. 1975. Appearance of newly synthesized protein in myelin of young rats. J. Neurochem. 24:1117–1122.

    Google Scholar 

  159. Benjamins, J. A. 1977. Myelin proteins: kinetics of entry. Trans. Am. Soc. Neurochem. 8:156 abstract.

    Google Scholar 

  160. Fischer, C. A., andMorell, P. 1974. Turnover of proteins in myelin and myelin-like material of mouse brain. Brain Res. 74:51–65.

    Google Scholar 

  161. Davison, A. N., andGregson, N. A. 1966. Metabolism of cellular membrane sulpholipids in the rat brain. Biochem. J. 98:915–922.

    Google Scholar 

  162. Banik, N. L., andDavison, A. N. 1971. Exchange of sterols between myelin and other membranes of developing rat brain. Biochem. J. 122:751–758.

    Google Scholar 

  163. Jungalwala, F. B., andDawson, R. M. C. 1971. The turnover of myelin phospholipids in the adult and developing rat brain. Biochem. J. 132:683–693.

    Google Scholar 

  164. Druse, M. J., Brady, R. O., andQuarles, R. H. 1974. Metabolism of a myelin-associated glycoprotein in developing rat brain.

  165. Sammeck, R., Martenson, R. E., andBrady, R. O. 1971. Studies of the metabolism of myelin basic proteins in various regions of the central nervous system. Brain Res. 34:241–254.

    Google Scholar 

  166. Davison, A. N. 1961. Metabolically inert proteins of the central nervous system, muscle and tendon. Biochem. J. 78:272–282.

    Google Scholar 

  167. Wood, J. G., andKing, N. 1971. Turnover of basic protein of rat brain. Nature 229:56–57.

    Google Scholar 

  168. Smith, M. E. 1968. The turnover of myelin in the adult rat. Biochim. Biophys. Acta 164:285–293.

    Google Scholar 

  169. Smith, M. E. 1972. The turnover of myelin proteins. Neurobiol. 2:35–40.

    Google Scholar 

  170. Sabri, M. I., Bone, A. H., andDavison, A. N. 1974. Turnover of myelin and other structural proteins in the developing rat brain. Biochem. J. 142:499–507.

    Google Scholar 

  171. Agrawal, H. C., Fujmoto, K., andBurton, R. M. 1976. Accumulation and turnover of the classical Folch-Lees proteolipid proteins in developing and adult rat brain. Biochem. J. 154:265–269.

    Google Scholar 

  172. Singh, H., andJungalwala, F. B. 1977. Turnover of rat brain myelin proteins. Trans. Am. Soc. Neurochem. 8:155 abstract.

    Google Scholar 

  173. Shapira, R., McKneally, S., Re, P. K., andKibler, R. F. 1972. Turnover of myelin basic protein in the mature rabbit. Trans. Am. Soc. Neurochem. 3:120 abstract.

    Google Scholar 

  174. Lajtha, A., Toth, J., Fujimoto, K., andAgrawal, H. C. 1977. Turnover of myelin proteins in mouse brain in vitro. Biochem. J. 164:323–329.

    Google Scholar 

  175. Glasgow, M. S., Quarles, R. H., andGrollman, S. 1972. Metabolism of fucoglycoproteins in the developing rat brain. Brain Res. 42:129–137.

    Google Scholar 

  176. Webster, H. D. 1971. The geometry of peripheral myelin sheaths during their formation and growth in rat sciatic nerves. J. Cell Biol. 48:348–367.

    Google Scholar 

  177. Morris, S. J., Louis, C. F., andShooter, E. M. 1971. Separation of myelin proteins on two different polyacrylamide gel systems. Neurobiol. 1:64–67.

    Google Scholar 

  178. Csejtey, J., Hallpike, J. F., Adams, C. W. M., andBayliss, O. B. 1972. Histochemistry of myelin XIV. Peripheral nerve myelin proteins: electrophoretic and histochemical correlations. J. Neurochem. 19:1931–1935.

    Google Scholar 

  179. Greenfield, S., Brostoff, S., Eylar, E. H., andMorell, P. 1973. Protein composition of myelin of the peripheral nervous system. J. Neurochem. 20:1207–1216.

    Google Scholar 

  180. Wood, J. G., andDawson, R. M. C. 1973. A major myelin glycoprotein of sciatic nerve. J. Neurochem. 21:717–719.

    Google Scholar 

  181. Singh, H., andSpritz, N. 1974. Polypeptide components of myelin from rat peripheral nerve. Biochim. Biophys. Acta 351:379–386.

    Google Scholar 

  182. Wiggins, R. C., Benjamins, J. A., andMorell, P. (1975. Appearance of myelin proteins in rat sciatic nerve during development. Brain Res. 89:99–106.

    Google Scholar 

  183. Brostoff, S. W., Karkhanis, Y. D., Carlo, D. J., Reuter, W., andEylar, E. H. 1975. Isolation and partial characterzation of the major proteins of rabbit sciatic nerve myelin. Brain Res. 86:449–458.

    Google Scholar 

  184. Everly, J. L., Brady, R. O., andQuarles, R. H. 1973. Evidence that the major protein in rat sciatic nerve myelin is a glycoprotein. J. Neurochem. 21:329–334.

    Google Scholar 

  185. Kitamura, K., Suzuki, K., andUyemura, K. 1976. Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane. Biochim. Biophys. Acta 455:806–816.

    Google Scholar 

  186. Quarles, R. H., andEverly, J. L. 1977. Glycopeptide fractions prepared from purified central and peripheral rat myelin. Biochim. Biophys. Acta 466:176–186.

    Google Scholar 

  187. Roomi, M. W., Ishaque, A., Breckenridge, W. C., Khan, N., andEylar, E. H. 1977. The P0 protein: A glycoprotein of PNS myelin. Trans. Am. Soc. Neurochem. 8:158 abstract.

    Google Scholar 

  188. Wiggins, R. C., andMorell, P. 1976. Phosphorylation and fucosylation of proteins of sciatic nerve myelin. Trans. Am. Soc. Neurochem. 7:72 abstract.

    Google Scholar 

  189. Matthieu, J. M., Everly, J. L., Brady, R. O., andQuarles, R. H. 1975. (35S)sulfate incorporation into myelin glycoproteins. II. Peripheral nervous tissue. Biochim. Biophys. Acta 392:167–174.

    Google Scholar 

  190. Brostoff, S. W., andEylar, E. H. 1972. The proposed amino acid sequence of the P1 protein of rabbit sciatic nerve myelin. Arch. Biochim. Biophys. 153:590–598.

    Google Scholar 

  191. Brostoff, S. W., Sacks, H., andDiPaola, C. 1975. The P2 protein of bovine root myelin: Partial chemical characterization. J. Neurochem. 24:289–294.

    Google Scholar 

  192. Singh, H., andSpritz, N. 1976. Protein kinases associated with peripheral nerve myelin. I. Phosphorylation of endogenous myelin proteins and exogenous substrates. Biochim. Biophys. Acta 448:325–337.

    Google Scholar 

  193. Singh, H., Silberlicht, I., andSingh, I. J. 1977. A comparative study of the polypeptides of sciatic nerve myelin. Trans. Am. Soc. Neurochem. 8:158 abstract.

    Google Scholar 

  194. Kirschner, D. A., andCaspar, D. L. D. 1977. Diffraction studies of molecular organization in myelin. Pages 51–89,In Morell, P. (ed.) Myelin, Plenum Press, New York.

    Google Scholar 

  195. Wood, J. G., andMcLaughlin, B. J. 1975. The visualization of concanavalin-A binding sites in the interperiod line of rat sciatic nerve myelin. J. Neurochem. 24:233–235.

    Google Scholar 

  196. Wood, J. G., andEngel, E. L. 1976. Peripheral nerve glycoproteins and myelin fine structure during development of rat sciatic nerve. J. Neurocytol. 5:605–615.

    Google Scholar 

  197. Gould, R. M. 1977. Incorporation of glycoproteins into peripheral nerve myelin. Trans. Am. Soc. Neurochem. 8:155 abstract.

    Google Scholar 

  198. Friede, R. L., andSamorajski, T. 1968. Myelin formation in the sciatic nerve of the rat. J. Neuropath. Exp. Neurol. 27:546–570.

    Google Scholar 

  199. Hedley-Whyte, E. T., Rawlins, F. A., Salpeter, M. M., andUzman, B. G. 1969. Distribution of cholesterol-1,2-3H during maturation of mouse peripheral nerve. Lab. Invest. 21:536–547.

    Google Scholar 

  200. Hedley-Whyte, E. T. 1973. Myelination of rat sciatic nerve: Comparison of under-nutrition and cholesterol synthesis inhibition. J. Neuropathol. Exp. Neurol. 32:284–302.

    Google Scholar 

  201. Rawlins, F. A. 1973. A time-sequence autoradiographic study of the in vivo incorporation of (1,2-3H)cholesterol into peripheral nerve myelin. J. Cell Biol. 58:42–53.

    Google Scholar 

  202. Rawlins, F. A., andSmith, M. E. 1971. Myelin synthesis in vitro: A comparative study of central and peripheral nervous tissue. J. Neurochem. 18:1861–1870.

    Google Scholar 

  203. Singer, S. 1974. The molecular organization of membranes. Annu. Rev. Biochem. 43:805.

    Google Scholar 

  204. Bretscher, M. S. 1973. Membrane structure: Some general principles. Membranes are asymmetric lipid bilayers in which cytoplasmically synthesized proteins are dissolved. Science 181:622.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benjamins, J.A., Morell, P. Proteins of myelin and their metabolism. Neurochem Res 3, 137–174 (1978). https://doi.org/10.1007/BF00964057

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00964057

Navigation