Conclusions
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1.
On radiolysis of deaerated solutions containing thymine and cysteamine, or thymidine monophosphate and cysteamine, coupling products of these compounds are formed resulting from the addition of cysteamine to the double bond of the base.
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2.
The radiochemical yields of the coupling products are dependent on the ratio of the concentration of thymine [T] to that of cysteamine [RSH], or of thymidine monophosphate [TMP] to cysteamine in the irradiated solutions, and are at a maximum when [T]/[RSH]=5–10, and [TMP]/[RSH]=15–20.
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3.
The mode of formation of coupling products involves reaction of H-, OH-, and eaq-adducts of thymine or thymidine monophosphate with cysteamine thiyl radicals.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2351–2358, October, 1985.
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Grachev, S.A., Kropachev, E.V. & Litvyakova, G.I. Addition of cysteamine to thymine and thymidine monophosphate, initiated by γ-irradiation. Russ Chem Bull 34, 2178–2184 (1985). https://doi.org/10.1007/BF00963257
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DOI: https://doi.org/10.1007/BF00963257