Conclusions
A quadrant rule is proposed for the enantioselective reduction of acetophenone by chiral hydrides based on LiAlH4, NaBH4, LiBH4, and BH3. This enables the configuration of the product to be explained and predicted, depending on the preferred conformations of the ligands in these hydrides.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 843–848, April, 1987.
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Pavlov, V.A., Simonova, T.V. & Klabunovskii, E.I. Asymmetric reduction of the carbonyl group by chiral hydrides. 1. Stereochemical considerations. Russ Chem Bull 36, 770–775 (1987). https://doi.org/10.1007/BF00962317
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DOI: https://doi.org/10.1007/BF00962317