[2+4]-Cycloaddition reactions of methyl trifluoropyruvate trifluoroacetylimine
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Methyl trifluoropyruvate trifluoroacetylimine (I) reacts regioselectively with olefins to form dihydrooxazines (II)-(VII). In its reactions with 1,3-dienes, too, compound (I) exhibits properties of a 1,3-heterodiene rather than a dienophile. Acid hydrolysis of the synthesized oxazines results in their conversion to substituted α-amino-α-trifluoromethyltetrahydrofuran-2-ones (XII)-(XVI).
KeywordsMethyl Hydrolysis Acid Hydrolysis Cycloaddition Reaction Oxazine
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