The possible relationship between the pineal gland and red cell destruction by the spleen

  • G. Barbolini
  • C. Barbanti
  • G. P. Trentini


After pinealectomy we were able to observe an accumulation of iron pigment in the histiocytes of the cords and of the follicles of the spleen in the rat, parallel with a slight increase in the enzymatic activity of the histiocytes and hypertrophy of the argentophil reticulum. The accumulation of iron and the enzymatic activity can be further increased by subcutaneous injection of trypan blue.

The working hypothesis is proposed that pinealectomy leads directly to an increase in the histiocytic activity in general and in the red cell destruction by the spleen in particular.


Public Health Iron Enzymatic Activity Trypan Blue Subcutaneous Injection 
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Über eine mögliche Beziehung zwischen der Glandula pinealis und dem Abbau von Erythrocyten in der Milz


Nach Pinealektomie konnte eine Anhäufung von Eisenpigment in den Histiocyten der Pulpastränge und der Follikel in der Rattenmilz festgestellt werden; parallel damit ging eine leichte Erhöhung der enzymatischen Aktivität der Histiocyten und eine Hypertrophie des argyrophilen Reticulums. Die Anhäufung von Eisenpigment und Erhöhung der enzymatischen Aktivität kann weiter gesteigert werden durch subcutane Injektion von Trypan-Blau. Folgende Arbeitshypothese wird zur Erklärung dieser Tatsache vorgeschlagen: Die Pinealektomie führt unmittelbar zu einer Erhöhung der Aktivität der Histiocyten im allgemeinen und des Abbaues der roten Blutkörperchen durch die Milz im besonderen.


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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • G. Barbolini
    • 1
  • C. Barbanti
    • 1
  • G. P. Trentini
    • 1
  1. 1.Istituto di Anatomia e Istologia Patologica dell'Universitá di ModenaItalia

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