Synthesis of esters of 2-substituted 4-ketopentanoic acids by the alkylation of CH-acids using chloroacetone under phase transfer catalysis conditions

  • A. Yu. Sizov
  • L. A. Yanovskaya
  • V. A. Dombrovskii
Brief Communications


An improved method was developed for the synthesis of ethyl esters of 2-substituted 4- ketopentanoic acids by the alkylation of CH2(X)CO2Et using chloroacetone in the liquid- solid KOH (K2CO3or Na2CO3DMF-PhCH2(Et)3NCl system.


Ester Ethyl Catalysis Alkylation Ethyl Ester 
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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • A. Yu. Sizov
    • 1
  • L. A. Yanovskaya
    • 1
  • V. A. Dombrovskii
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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