Summary
The types of glomerular alterations in mice after repeated intraperitoneal injections of egg albumin over several weeks are studied. The application of different amounts of this foreign protein results either in glomerulonephritis or glomerulonephrosis, antigenantibody complexes apparently being in any case the leading pathogenic factor. The resulting glomerular alterations, in relation to presumably different compositions of the antigenantibody complexes, are discussed. An incomplete immunologie unresponisveness after great amounts of egg albumin seems to modify the composition of the antigen-antibody complexes in such a way that there appears the picture of a glomerulonephrosis.
Zusammenfassung
TÄgliche intraperitoneale Injektionen von Ovalbumin über mehrere Wochen führen bei der Maus zu GlomerulumverÄnderungen, die — in AbhÄngigkeit von der Dosis des applizierten Fremdeiwei\es —, einer Glomerulonephritis oder einer Glomerulonephrose entsprechen. Dabei scheinen zirkulierende Antigen-Antikörper-Komplexe (AAK), die sich in den Glomerula niederschlagen, den pathogenetisch wichtigsten Faktor darzustellen. Das Spektrum der morphologischen Befunde dürfte durch Unterschiede in der Zusammensetzung der jeweiligen AAK bedingt sein. Diese wird nach Applikation relativ hoher Ovalbumindosen durch das Auftreten einer partiellen Immunparalyse offenbar soweit verÄndert, da\ das Bild einer Glomerulonephrose resultiert.
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Stipendiat der Forschungskommission der UniversitÄt Basel.
Wesentliche Teile der vorliegenden Arbeit werden von HerrnFresen als Dissertation der medizinischen FakultÄt der UniversitÄt Freiburg i.Br. vorgelegt.
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Moppert, J., Fresen, K.O. Experimentelle Glomerulonephritis und Glomerulonephrose bei der Maus nach wiederholten Ovalbumininjektionen. Virchows Arch. path Anat. 342, 304–318 (1967). https://doi.org/10.1007/BF00960485
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DOI: https://doi.org/10.1007/BF00960485