Simple method for the synthesis of bicyclic pyridine bases from 1-ethynylcycloalkanols and carboxylic acid chlorides

  • F. A. Selimov
  • O. G. Rutman
  • U. M. Dzhemilev
Organic Chemistry


A new, simple and effective method was developed for the synthesis of difficultly obtainable bicyclic pyridine bases by the condensation of cyclic ethynylcarbinols with carboxylic acid anhydrides in the presence of an equimolar ZnCl2-POCl3 mixture followed by treatment with ammonium hydroxide.


Chloride Ammonium Hydroxide Pyridine Anhydride 
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Literature cited

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • F. A. Selimov
    • 1
  • O. G. Rutman
    • 1
  • U. M. Dzhemilev
    • 1
  1. 1.Institute of Chemistry, Bashkir Scientific Center, Urals BranchAcademy of Sciences of the USSRUfa

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