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Synthesis of novel thiazoles bearing hydrazine, thiosemicarbazide, thiazole, and thiazolidinone moieties

  • Organic Chemistry
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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Abstract

Thiazolecarboxylate esters (I) and (II) react with hydrazine hydrate to give the acid hydrazides (III) and (IV), which then react with KSCN and PhNCS to give high yields of the thiosemicarbazides (V)-(VIII). Cyclocondensation of the thiosemicarbazide (V) with 3-phenyl-3-chloro-2-oxopropionic acid derivatives gives compounds with two thiazole moieties (IX)-(XIV). The reaction of the phenylthiosemicarbazides (VII) and (VIII) with chloroacetyl chloride and (or) chloroacetic acid affords the thiazolidinonethiazoles (XV) and (XVI).

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Science Center, Academy of Sciences of the USSR, USSR

    V. A. Mamedov, I. A. Nuretdinov & F. G. Sibgatullina

Authors
  1. V. A. Mamedov
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  2. I. A. Nuretdinov
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  3. F. G. Sibgatullina
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2832–2836, December, 1991.

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Mamedov, V.A., Nuretdinov, I.A. & Sibgatullina, F.G. Synthesis of novel thiazoles bearing hydrazine, thiosemicarbazide, thiazole, and thiazolidinone moieties. Russ Chem Bull 40, 2470–2474 (1991). https://doi.org/10.1007/BF00959725

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  • DOI: https://doi.org/10.1007/BF00959725

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