Abstract
Acetate and malonate, basic precursors in the biosynthesis of polyketides, were added to suspension cultures ofRhammus purshiana DC. It was found that the production of anthra-derivatives (i.e. 1,8-dihydroxyanthraquinones, anthrones and-or dianthrones) in these cultures was significantly stimulated by malonate, while addition of acetate had an inhibitory effect under similar conditions.
Similar content being viewed by others
References
De Vellis, J., Shannon, L.M., Lew, J.Y. (1963) Malonic acid biosynthesis in bush bean roots. I. Evidence for oxaloacetate as immediate precursor. Plant Physiol.38, 686–690
Gamborg, O.L. (1975) Callus and cell culture. In: Plant tissue culture methods, pp. 1–10, Gamborg, O.L., Wetter, L.R., eds. National Research Council of Canada, Saskatoon, Saskatchewan
Gstraunthaler, G.J.A. (1983) The effect of cerulenin on fatty acid and anthraquinone biosynthesis in vegetative mycelia ofCortinarius orichalceus. Fr. Biochim. Biophys. Acta750, 424–427
Hatch, M.D., Stumpf, P.K. (1962) Fat metabolism in higher plants. XVII. Metabolism of malonic acid and its aiphasubstituted derivatives in plants. Plant Physiol.37, 121–126
Labadie, R.P. (1970) The anthracene derivatives inRhammus frangula L., I. The aglycones. Pharm. Weekbl.105, 189–195
Leistner, E., Zenk, M.H. (1969) Chrysophanol (1,8-dihydroxy-3-methyl-anthraquinone) biosynthesis in higher plants. Chem. Commun. 210–211
Mann, J. (1978) Secondary metabolism, pp. 1–77, Oxford University Press, Oxford
Murashige, T., Skoog, F. (1962) A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiol. Plant.15, 473–497
Sedgwick, B. (1973) The control of fatty acid biosynthesis in plants. In: Biosynthesis and its control in plants. pp. 179–217, Milborrow, B.V., ed. Academic Press, London New York
Shannon, L.M., De Vellis, J., Lew, J.Y. (1963) Malonic acid biosynthesis in bush bean roots. II. Purification and properties of enzyme catalyzing decarboxylation of oxaloacetate. Plant Physiol.38, 691–697
Van den Berg, A.J.J. (1987) Production of anthraquinones, anthrones and dianthrones by plant cell cultures ofRhamnus purshiana andRhamnus frangula. Thesis, State University of Utrecht
Van den Berg, A.J.J., Labadie, R.P. (1981) Production of acetate derived hydroxyanthraquinones,-dianthrones,-naphthalenes and-benzenes in tissue cultures ofRumex alpinus. Planta Med.41, 169–173
Van den Berg, A.J.J., Labadie, R.P. (1984) Anthraquinones, anthrones and dianthrones in callus cultures ofRhammus frangula andRhamnus purshiana. Planta Med.50, 449–451
Van den Berg, A.J.J., Labadie, R.P. (1985) High performance liquid chromatographic separation and quantitative determination of 1,8-dihydroxyanthraquinones in plant cell cultures. J. Chromatogr.329, 311–314
Van den Berg, A.J.J., Radema, M.H., Labadie, R.P. (1985) Production of 1,8-dihydroxyanthracene derivatives in callus and suspension cultures ofRhammus purshiana. Pharm. Ztg.130, 2315
Van den Berg, A.J.J., Radema, M.H., Labadie, R.P. (1987) Influence of malonate on the production of polyketide anthraquinones in suspension cultures ofRhamnus frangula. Pharm. Weekbl. Sci. Edition9, 157
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van den Berg, A.J.J., Radema, M.H. & Labadie, R.P. Influence of acetate and malonate on the production of 1,8-dihydroxyanthracene derivatives in suspension cultures ofRhamnus purshiana . Planta 174, 417–421 (1988). https://doi.org/10.1007/BF00959529
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00959529