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Friedel-Crafts alkylation of benzene by normal ω-chloroalkanoic acids and their methyl esters and nitriles

  • Organic Chemistry
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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

In the alkylation of benzene by ω-chloroalkanoic acids Cl(CH2)nCOOH (where n=3–6) and their methyl esters and nitriles, in the presence of A1C13, the degree of isomerization of the alkyl chain is less than with the corresponding 1-chloroalkanes, depending on the increase in electron acceptor activity in the sequence HOOC-> CH3OCO-> CN-.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    L. I. Zakharkin & E. V. Anikina

Authors
  1. L. I. Zakharkin
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  2. E. V. Anikina
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 367–371, February, 1987.

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Zakharkin, L.I., Anikina, E.V. Friedel-Crafts alkylation of benzene by normal ω-chloroalkanoic acids and their methyl esters and nitriles. Russ Chem Bull 36, 327–330 (1987). https://doi.org/10.1007/BF00959375

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  • DOI: https://doi.org/10.1007/BF00959375

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