Genetica

, Volume 41, Issue 1, pp 589–625 | Cite as

An analysis of white-mottled mutants inDrosophila hydei, with observations on X-Y exchanges in the male

  • F. M. A. van Breugel
Article

Abstract

Chromosomes and phenotypes of four different sex-linkedwhite-mottled mutants of the position-effect variogation type were studied. Three mutants (wm1,wm2,wm3) are X-chromosomal rearrangements which shift the w+ locus into a position close to heterochromatin, but which have different ouchromatic and heterochromatic breaks. The fourth, a spontaneous derivative ofwm1, is an insertional duplication of part of the X chromosome, including thew+ andN+loci. The duplicated segment is inserted into the distal part of the long arm of the heterochromatic Y chromosome. It is designated,wmCoY, orXwmCo when transferred to the X chromosome.

Three chromosomal types (wm1,wmCoY) and (XwmCo) having the same cuchromatic break near thew+ locus, cause large-spotted eyes whereas two others (wm2,wm3) produce a popper-and-salt type of mottling. From the position of the various eu- and heterochromatic breaks, it appears that the distance of thew+ locus to the point of reunion with heterochromatin, rather than the amount or type of adjoining heterochromatin, dietates the phenotypic action of the displacedw+ locus, in the sense of a spreading effect on two proposed functional subunits within thew+ locus.

The pigmentation background against which the mottling effect is produced, i.e., a givenw-allele with its characteristic colour, or other eye colour mutations, does not seem to affect the type of mottling. Drosopterins and ommochromes react in the same way to modifing factors like temperature and supernumerary Y chromosomes. Two mutants (wm2 andwmCoY) while reacting in the same manner to Y chromosomes showed an opposite temperature response.

By exchange between the heterochromatin of the Y and X chromosome inw/wmCoY males thewmCo duplication was transferred between the sex chromosomes with a certain regularity. It is not yet known wether the exchanges are mitotic or meiotic in origin but their heterochromatic nature has been demonstrated cytologically.

Keywords

Distal Part Temperature Response Characteristic Colour Spreading Effect Colour Mutation 

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Copyright information

© Martinus Nijhoff 1970

Authors and Affiliations

  • F. M. A. van Breugel
    • 1
  1. 1.Genetisch Laboratorium der RijksuniversiteitLeidenThe Netherlands

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