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The sex ratio in anencephaly

Genetica volume 41, pages 457–465 (1970)Cite this article

Abstract

It is shown that the well known excess of females in anencephalic births is statistically significant when compared with (a) the general population and (b) their normal sibs.

There is also a statistically significant difference between the sex ratio of anencephalic births and that of spina bifida births which suggests that there is a definite difference in the genetic component of their aetiology.

These results are discussed with reference to the genetics of anencephaly and spina bifida and a genetic model of the inheritance of the genetic component of anencephaly is given. The significance of a possible cytoplasmic factor is also considered.

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Affiliations

  1. University Department of Medical Genetics, The Royal Infirmary, Manchester, United Kingdom

    J. Timson

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  1. J. Timson
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Timson, J. The sex ratio in anencephaly. Genetica 41, 457–465 (1970). https://doi.org/10.1007/BF00958926

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  • DOI: https://doi.org/10.1007/BF00958926

Keywords

  • General Population
  • Genetic Model
  • Genetic Component
  • Spina Bifida
  • Definite Difference