Summary
Cortisone leads to damage of the epiphysial cartilage cells of young rabbits, and also of the osteoblasts in the metaphysis, which brings about a change in the appearance of the bone trabeculae in the metaphysis; growth and the faculty of the cartilage cells to produce chondroitin sulphate is reduced, as demonstrated by autoradiography. Combined treatment with vitamin A and cortisone leads to the same changes as cortisone alone. In combination with papain cortisone, during the first few days at any event, does not influence the effect of papain on the cartilage. Prolonged cortisone administration impedes the restitution of the papain-induced changes; the cartilage cells however regain their faculty of chondroitinsulphate synthesis despite the administration of cortisone as shown by autoradiography.
Zusammenfassung
Cortison führt bei jungen Kaninchen zu einer Schädigung der Zellen des Epiphysenknorpels und der Osteoblasten in der Metaphyse, so daß die knöchernen Trabekel in der Metaphyse ein verändertes Aussehen zeigen; das Wachstum ist deutlich vermindert, ebenso die Fähigkeit der Knorpelzellen, Chondroitinsulfat zu bilden, wie man autoradiographisch nachweisen kann. Kombinierte Behandlung der Tiere mit Vitamin A und Cortison führt zu denselben Veränderungen wie Cortison allein. Mit Papain kombiniert, beeinflußt Cortison wenigstens während der ersten Tage nicht die Wirkung des Papains auf den Knorpel; längere Cortisonzufuhr hindert die Wiederherstellung nach den durch Papain verursachten Veränderungen. Wie die Autoradiographie zeigt, gewinnen jedoch die Knorpelzellen trotz der Cortisongaben ihre Fähigkeit zurück, Chondroitinsulfat zu synthetisieren.
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Hulth, A., Westerborn, O. Effect of cortisone on the epiphysial cartilage. Virchows Arch. path Anat. 336, 209–219 (1963). https://doi.org/10.1007/BF00957910
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DOI: https://doi.org/10.1007/BF00957910