Anatomy and Embryology

, Volume 184, Issue 4, pp 331–335 | Cite as

Origin and characterization of atrial natriuretic peptide in the rat parotid gland

  • Angelika M. Vollmar
  • Florian Colbatzky
  • Walter Hermanus
  • Rüdiger Schutz


The heart atria represent the major site of synthesis for atrial natriuretic peptide (ANP) which exerts potent natriuretic, diuretic and vasoactive functions. Recently, ANP-immunoreactivity has been detected in extracardial organs involved in water and electrolyte homeostasis, such as the intestine and certain exocrine glands. The present study investigates ANP in the parotid gland. It was found by immunohistochemical techniques that the peptide is localized in ductal cells of the gland. An analysis of the immunoreactive material by high-pressure liquid chromatography and radioimmunoassay revealed the prohormone of ANP (ANP 1-126) and the biologically active fragment (ANP 99-126). Furthermore, Northern blot hybridization disclosed the presence of mRNA coding for ANP. It is suggested that ANP is synthesized and released from the parotid gland and functions in the control of saliva production.

Key words

Atrial natriuretic peptide (ANP) ANP-mRNA Rat parotid gland 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Angelika M. Vollmar
    • 1
  • Florian Colbatzky
    • 2
  • Walter Hermanus
    • 2
  • Rüdiger Schutz
    • 1
  1. 1.Institute of Pharmacology, Toxicology and PharmacyUniversity of MunichMünchen 22Germany
  2. 2.Institute of Veterinary PathologyUniversity of MunichMünchen 22Germany

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