Structure and properties of diphenylacetylbenzo-12-crown-4
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It has been shown by x-ray structural examination and IR spectroscopy that conformations of diphenylacetylbenzo-12-crown-4 in which the lone pairs of oxygen are oriented on opposite sides of the plane of the macrocycle are stabilized in the crystal and in solution. From a comparison with the structure and anticonvulsant activity of benzo-12-crown-4 with those of its acetyl and diphenylacetyl derivatives, it is suggested that a condition for the possition of this type of activity is the presence of a conformation of the macrocycle in which the lone pairs of the three oxygen atoms are located on the same side.
KeywordsOxygen Spectroscopy Oxygen Atom Acetyl Lone Pair
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