Structure and properties of diphenylacetylbenzo-12-crown-4

  • O. A. Raevskii
  • V. V. Tkachev
  • V. P. Kazachenko
  • A. N. Razdol'skii
  • V. E. Zubareva
  • I. I. Bulgak
Physical Chemistry
  • 21 Downloads

Abstract

It has been shown by x-ray structural examination and IR spectroscopy that conformations of diphenylacetylbenzo-12-crown-4 in which the lone pairs of oxygen are oriented on opposite sides of the plane of the macrocycle are stabilized in the crystal and in solution. From a comparison with the structure and anticonvulsant activity of benzo-12-crown-4 with those of its acetyl and diphenylacetyl derivatives, it is suggested that a condition for the possition of this type of activity is the presence of a conformation of the macrocycle in which the lone pairs of the three oxygen atoms are located on the same side.

Keywords

Oxygen Spectroscopy Oxygen Atom Acetyl Lone Pair 

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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • O. A. Raevskii
    • 1
    • 2
    • 3
  • V. V. Tkachev
    • 1
    • 2
    • 3
  • V. P. Kazachenko
    • 1
    • 2
    • 3
  • A. N. Razdol'skii
    • 1
    • 2
    • 3
  • V. E. Zubareva
    • 1
    • 2
    • 3
  • I. I. Bulgak
    • 1
    • 2
    • 3
  1. 1.Institute of Physiologically Active CompoundsAcademy of Sciences of the USSRChernogolovka
  2. 2.Department of the Institute of Chemical PhysicsAcademy of Sciences of the USSRChernogolovka
  3. 3.Institute of ChemistryAcademy of Sciences of the Moldavian SSRKishinev

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