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A general method for the asymmetric synthesis of α-amino acids by the alkylation of glycine in chiral Ni(II) complexes

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusion

The asymmetric synthesis of S-Ala, S-Val, S-Trp, S-Phe, S-Nle, and S-3,4-dimethoxy-Phe with optical yields of about 90% is carried out by the alkylation of glycine in Ni(II) complexes of its Schiff base with S-2-N-(N'-benzylpropyl) aminobenzophenone by the action of NaOH in DMF or acetonitrile.

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Literature cited

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    Yu. N. Belokon', N. I. Chernoglazova, N. S. Garbalinskaya, M. B. Saporovskaya, K. A. Kochetkov & V. M. Belikov

Authors
  1. Yu. N. Belokon'
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  2. N. I. Chernoglazova
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  3. N. S. Garbalinskaya
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  4. M. B. Saporovskaya
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  5. K. A. Kochetkov
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  6. V. M. Belikov
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2340–2342, October, 1986.

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Belokon', Y.N., Chernoglazova, N.I., Garbalinskaya, N.S. et al. A general method for the asymmetric synthesis of α-amino acids by the alkylation of glycine in chiral Ni(II) complexes. Russ Chem Bull 35, 2142–2144 (1986). https://doi.org/10.1007/BF00957546

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  • DOI: https://doi.org/10.1007/BF00957546

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