Chemistry of Heterocyclic Compounds

, Volume 5, Issue 5, pp 681–682 | Cite as

Synthesis of derivatives of 1, 2, 4-triazole-3, 5-dicarboxylic acid

  • T. N. Vereshchagina
  • V. A. Lopyrev
  • M. S. Pevzner
  • L. M. Kogan
Article

Abstract

By oxidation of 3,5-dimethyl-1,2,4-triazole the monopotassium salt of 1,2,4-triazole-3,5-dicarboxylic acid was obtained. The mononitryl of 1,2,4-triazole-3,5-dicarboxylic acid was isolated during the reaction between 3-diazo-1,2,4-triazole-5-carboxylic acid and potassium cyanide in the presence of copper cyanide. Acid hydrolysis of 3-cyano-1,2,4-triazole-5-carboxylic acid leads to the formation of 3-carbamido-5-carboxy-1,2,4-trlazole, which on esterification with methanol gives rise to 3-carbamido-5-carbomethoxy-1,2,4-triazole.

Keywords

Oxidation Copper Methanol Potassium Hydrolysis 

References

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    English patent no. 816531, 1959; Chemical abstracts,54, 1552, 1960.Google Scholar
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    G. I. Chipen and V. Ya. Grinshtein, Izv. AN Latv. SSR, ser. khim., 204, 1965.Google Scholar
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    E. N. Zil'berman and A. E. Kulikova, ZhOKh,29, 3039, 1959.Google Scholar
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    I. Ya. Postovskii and N. N. Vereshchagina, ZhOKh, 29, 2139, 1959.Google Scholar

Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • T. N. Vereshchagina
    • 1
    • 2
  • V. A. Lopyrev
    • 1
    • 2
  • M. S. Pevzner
    • 1
    • 2
  • L. M. Kogan
    • 1
    • 2
  1. 1.North-Western Extra-Mural Polytechnic InstituteLeningrad
  2. 2.Lensovet Leningrad Technological InstituteUSSR

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