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Electron microscopic study of anterior pituitary necrosis caused by hexadimethrine bromide in rats

  • K. Kovács
  • Sz. VirÁgh
  • T. Tiboldi
Article

Summary

Intravenous injection of hexadimethrine bromide in rats causes necrosis of the anterior pituitary. As early as after half an hour there is dilatation of the vessels, slight intravascular fibrin precipitation, rupture of the vessel walls, and leaking of plasma into the spaces between the parenchymal cells. At one hour, platelets accumulate around the small fibrin coagula and also become attached to the ruptures of the vascular walls; these may occlude the capillary lumen. The necrosis of the parenchyma becomes recognizable later, and is apparently secondary. The necrosis is thus considered to be the result of a local circulatory disturbance.

Keywords

Public Health Precipitation Bromide Vessel Wall Intravenous Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Elektronenmikroskopische Untersuchungen der Nekrose des Hypophysenvorderlappens, hervorgerufen durch Hexadimethrin-Bromid bei Ratten

Zusammenfassung

Schon nach 30 min findet man eine Erweiterung der Gefäße, geringe intravasculäre Fibrinniederschläge, Einrisse der Gefäßwände und Austritt von Plasma in die Zwischenräume zwischen die Parenchymzellen. Nach 60 min sammeln sich Thrombocyten um die kleinen Fibrincoagula an und haften an den Stellen der Gefäßeinrisse. So dürfte es zu einem Verschluß der Capillarlichtungen kommen. Die Parenchymnekrose wird erst später erkennbar und ist offenbar sekundärer Natur — sie wird also als Folge der örtlichen Kreislaufstörung aufgefaßt.

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References

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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • K. Kovács
    • 1
    • 2
  • Sz. VirÁgh
    • 1
    • 2
  • T. Tiboldi
    • 1
    • 2
  1. 1.Ist Department of MedicineUniversity Medical SchoolSzeged
  2. 2.Department of Histology and EmbryologyUniversity Medical SchoolBudapestHungary

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